Standardized measurement of abdominal muscle by computed tomography: association with cardiometabolic risk in the Framingham Heart Study.
Standardized measurement of abdominal muscle by computed tomography: association with cardiometabolic risk in the Framingham Heart Study.
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DOI：
10.1007/s00330-022-08934-w
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发表时间：
2022-10
影响因子：
5.9
通讯作者：
Hoffmann, Udo
中科院分区：
文献类型：
--
作者：
Kammerlander, Andreas;Lyass, Asya;Mahoney, Taylor F.;Taron, Jana;Eslami, Parastou;Lu, Michael T.;Long, Michelle T.;Vasan, Ramachandran S.;Massaro, Joseph M.;Hoffmann, Udo
提供计算机断层扫描（CT）上的总腹肌质量（TAM）量化标准，并研究其与一级预防中心血管风险的相关性。我们纳入了3016例无心血管疾病（CVD）的心脏病研究参与者，他们在2002年至2005年期间接受了腹部CT检查。在L3/L4水平的单个CT切片上，我们分割（1）TAM-面积，（2）TAM-指数（= TAM-面积/高度）和（3）TAM-分数（= TAM-面积/总横截面CT面积）。我们在11.0 ± 2.7年的随访中检测了这些肌肉质量指标与流行和偶发心脏代谢危险因素以及偶发CVD事件的相关性。在这个以社区为基础的样本中（49%的女性，平均年龄：50.0 ± 10.0岁），所有肌肉数量测量与流行和偶发的心脏代谢危险因素和CVD事件显著相关。然而，只有TAM分数仍然与关键结果显著相关（例如，校正年龄、性别、体重指数和腰围后，高血压和CVD事件的OR分别为0.68 [0.55，0.84]和HR分别为0.73 [0.57，0.92]。此外，只有较高的TAM分数与较低的风险相关（例如，糖尿病事件与TAM-面积的调整OR：0.56 [0.36-0.89]：调整OR 1.26 [0.79-2.01]和TAM-指数：1.09 [0.75-1.58]。在L3/L4的单个CT切片上的TAM分数是一种新的身体组成标志物，在一级预防环境中具有改善风险分层的潜力，超越了传统的肥胖指标。·在这项心脏研究的分析中（n = 3016），与单独的TAM或以体表面积为指标的TAM相比，单层CT上的TAM-F与流行和偶发心脏代谢风险因素的关系更密切。·在L3/L4水平的单个腹部CT切片上的TAM-F可以作为肌肉质量的标准测量并改善风险预测
To provide a standard for total abdominal muscle mass (TAM) quantification on computed tomography (CT) and investigate its association with cardiovascular risk in a primary prevention setting. We included 3016 Framingham Heart Study participants free of cardiovascular disease (CVD) who underwent abdominal CT between 2002 and 2005. On a single CT slice at the level of L3/L4, we segmented (1) TAM-Area, (2) TAM-Index (= TAM-Area/height) and, (3) TAM-Fraction (= TAM-Area/total cross-sectional CT-area). We tested the association of these muscle mass measures with prevalent and incident cardiometabolic risk factors and incident CVD events during a follow-up of 11.0 ± 2.7 years. In this community-based sample (49% women, mean age: 50.0 ± 10.0 years), all muscle quantity measures were significantly associated with prevalent and incident cardiometabolic risk factors and CVD events. However, only TAM-Fraction remained significantly associated with key outcomes (e.g., adj. OR 0.68 [0.55, 0.84] and HR 0.73 [0.57, 0.92] for incident hypertension and CVD events, respectively) after adjustment for age, sex, body mass index, and waist circumference. Moreover, only higher TAM-Fraction was associated with a lower risk (e.g., adj. OR: 0.56 [0.36–0.89] for incident diabetes versus TAM-Area: adj. OR 1.26 [0.79–2.01] and TAM-Index: 1.09 [0.75–1.58]). TAM-Fraction on a single CT slice at L3/L4 is a novel body composition marker of cardiometabolic risk in a primary prevention setting that has the potential to improve risk stratification beyond traditional measures of obesity. • In this analysis of the Framingham Heart Study (n = 3016), TAM-F on a single slice CT was more closely associated with prevalent and incident cardiometabolic risk factors as compared to TAM alone or TAM indexed to body surface area. • TAM-F on a single abdominal CT slice at the level of L3/L4 could serve as a standard measure of muscle mass and improve risk prediction
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