Bilateral collicular interaction: modulation of auditory signal processing in amplitude domain.
Bilateral collicular interaction: modulation of auditory signal processing in amplitude domain.
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双边丘脑相互作用：幅度域中听觉信号处理的调制
DOI：
10.1371/journal.pone.0041311
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Chen QC
中科院分区：
文献类型：
--
作者：
Mei HX;Cheng L;Tang J;Fu ZY;Wang X;Jen PH;Chen QC
在上行听觉通路中，下丘 (IC) 接收并整合来自许多下听觉核团、IC 内的内在投射、通过 IC 连合的对侧 IC 和听觉皮层的兴奋性和抑制性输入。所有这些连接使 IC 成为皮层下听觉信息时间和频谱整合的主要中心。在这项研究中，我们利用电生理记录、声学和局部电刺激来检查双侧丘脑在调节幅度域信号处理中的相互作用。一个（同侧）IC 的局部电刺激对另一个（对侧）IC 中的神经元反应产生广泛的抑制（61.6%）和集中促进（9.1%），而 29.3% 的神经元不受影响。双侧丘脑相互作用使受抑制的 IC 神经元的反应幅度降低并增加反应潜伏期，但对促进的 IC 神经元的反应产生相反的影响。这两组神经元并不是分开定位的，而是在 IC 内按音调组织的。调制效果在低声级时最有效，并且取决于声刺激和电刺激之间的间隔。同侧 IC 的局部电刺激会压缩或扩展对侧 IC 神经元的速率水平功能。局部电刺激还会使对侧 IC 神经元的最小阈值和动态范围产生长达 150 分钟的变化。双侧丘脑相互作用的程度取决于电刺激的 IC 神经元和调制的 IC 神经元之间的最佳频率的差异。这些数据表明，双侧丘脑相互作用主要改变信号处理过程中兴奋和抑制的比例，从而提高IC神经元的幅度敏感性。双边相互作用也可能与 IC 中声学体验相关的可塑性有关。讨论了双侧丘脑相互作用的三种可能的神经通路。
In the ascending auditory pathway, the inferior colliculus (IC) receives and integrates excitatory and inhibitory inputs from many lower auditory nuclei, intrinsic projections within the IC, contralateral IC through the commissure of the IC and from the auditory cortex. All these connections make the IC a major center for subcortical temporal and spectral integration of auditory information. In this study, we examine bilateral collicular interaction in modulating amplitude-domain signal processing using electrophysiological recording, acoustic and focal electrical stimulation. Focal electrical stimulation of one (ipsilateral) IC produces widespread inhibition (61.6%) and focused facilitation (9.1%) of responses of neurons in the other (contralateral) IC, while 29.3% of the neurons were not affected. Bilateral collicular interaction produces a decrease in the response magnitude and an increase in the response latency of inhibited IC neurons but produces opposite effects on the response of facilitated IC neurons. These two groups of neurons are not separately located and are tonotopically organized within the IC. The modulation effect is most effective at low sound level and is dependent upon the interval between the acoustic and electric stimuli. The focal electrical stimulation of the ipsilateral IC compresses or expands the rate-level functions of contralateral IC neurons. The focal electrical stimulation also produces a shift in the minimum threshold and dynamic range of contralateral IC neurons for as long as 150 minutes. The degree of bilateral collicular interaction is dependent upon the difference in the best frequency between the electrically stimulated IC neurons and modulated IC neurons. These data suggest that bilateral collicular interaction mainly changes the ratio between excitation and inhibition during signal processing so as to sharpen the amplitude sensitivity of IC neurons. Bilateral interaction may be also involved in acoustic-experience-dependent plasticity in the IC. Three possible neural pathways underlying the bilateral collicular interaction are discussed.
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影响因子：
2
作者：
Malmierca, MS;Hernández, O;Rees, A
通讯作者：
Rees, A
影响因子：
1.7
作者：
Hernandez, Olga;Rees, Adrian;Malmierca, Manuel S.
通讯作者：
Malmierca, Manuel S.
影响因子：
2.5
作者：
MALMIERCA, MS;REES, A;BJAALIE, JG
通讯作者：
BJAALIE, JG
影响因子：
2.5
作者：
HERBERT, H;ASCHOFF, A;OSTWALD, J
通讯作者：
OSTWALD, J
影响因子：
2.1
作者：
Popelár, J;Nwabueze-Ogbo, FC;Syka, J
通讯作者：
Syka, J