Associations between Per- and Polyfluoroalkyl Substances (PFAS) and Cardiometabolic Biomarkers in Adults of Czechia: The Kardiovize Study.
Associations between Per- and Polyfluoroalkyl Substances (PFAS) and Cardiometabolic Biomarkers in Adults of Czechia: The Kardiovize Study.
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DOI：
10.3390/ijerph192113898
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发表时间：
2022-10-26
影响因子：
--
通讯作者：
Gonzalez-Rivas, Juan P.
中科院分区：
文献类型：
--
作者：
Maranhao Neto, Geraldo A.;Polcrova, Anna Bartoskova;Pospisilova, Anna;Blaha, Ludek;Klanova, Jana;Bobak, Martin;Gonzalez-Rivas, Juan P.
尽管有证据表明捷克的全氟烷基和多氟烷基物质（PFAS）呈下降趋势，但PFAS污染的主要来源仍然存在。关于心脏代谢健康与PFAS之间关系的结果仍然不一致，本研究试图确定PFAS水平与心脏代谢生物标志物（包括捷克人群中的血压和代谢障碍驱动因素）之间的关联。对479名受试者（56.4%为女性，中位数：53岁，范围：25-89岁）进行了一项横断面研究。在血清中测量了四种PFAS：全氟辛酸（PFOA）、全氟壬酸（PFNA）、全氟癸酸（PFDA）和全氟辛烷磺酸（PFOS）。使用线性回归和平滑薄板样条，通过广义相加模型评估自然对数（ln）转换的PFAS和心脏代谢生物标志物之间的相关性，并对潜在混杂因素进行调整。有积极和显著的（p < 0.05）ln转化的PFOA和葡萄糖之间的关联（β = 0.01），收缩压（β = 0.76）和舒张压（β = 0.65）;总胆固醇（β = 0.07）和LDL-c（β = 0.04）;全氟辛烷磺酸与葡萄糖（β = 0.03）、BMI（β = 2.26）、腰围（β = 7.89）、收缩压（β = 1.18）、总胆固醇（β = 0.13）和HDL-c（β = 0.04）。PFNA与PFDA呈显著负相关。在四种全氟辛烷磺酸中，只有全氟辛酸和全氟辛烷磺酸显示出正相关性，即使血清浓度没有文献中的数值高。
Even though there is evidence of decreasing trends of per- and polyfluoroalkyl substances (PFAS) in Czechia, there are still major sources of PFAS pollution. Regarding the still-inconsistent results of the relationship between cardiometabolic health and PFAS, the present study sought to determine the association between PFAS levels and the presence of cardiometabolic biomarkers, including blood pressure and dysglycemia drivers in the Czech population. A cross-sectional study with 479 subjects (56.4% women, median: 53 years, range: 25–89) was conducted. Four PFAS were measured in serum: perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluorooctane sulfonate (PFOS). The associations between natural log (ln)-transformed PFAS and cardiometabolic biomarkers were assessed through generalized additive models using linear regression and smoothing thin plate splines, adjusted for potential confounders. There were positive and significant (p < 0.05) associations between the ln-transformed PFOA and glucose (β = 0.01), systolic (β = 0.76) and diastolic blood pressure (β = 0.65); total cholesterol (β = 0.07) and LDL-c (β = 0.04); and PFOS with glucose (β = 0.03), BMI (β = 2.26), waist circumference (β = 7.89), systolic blood pressure (β = 1.18), total cholesterol (β = 0.13), and HDL-c (β = 0.04). When significant, the correlations of PFNA and PFDA were negative. Of the four PFAS, only PFOA and PFOS showed a positive association, even in serum levels not as high as the values from the literature.
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影响因子：
3.7
作者：
MASSEY, FJ
通讯作者：
MASSEY, FJ
影响因子：
16.2
作者：
Lin CY;Chen PC;Lin YC;Lin LY
通讯作者：
Lin LY
DOI：
10.3390/ijerph19095455
发表时间：
2022-04-29
影响因子：
--
作者：
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通讯作者：
Obeng-Gyasi, Emmanuel
影响因子：
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作者：
Fisher, Mandy;Arbuckle, Tye E.;Haines, Douglas A.
通讯作者：
Haines, Douglas A.
DOI：
10.1016/j.ijheh.2018.08.014
发表时间：
2019-01-01
影响因子：
6
作者：
Christensen, Krista Y.;Raymond, Michelle;Meiman, Jon
通讯作者：
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