Short-term effects of sibutramine on mineral status and selected biochemical parameters in obese women.
Short-term effects of sibutramine on mineral status and selected biochemical parameters in obese women.
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西布曲明对肥胖女性矿物质状况和选定生化参数的短期影响。
DOI：
10.1007/s12011-012-9425-6
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发表时间：
2012-11
影响因子：
3.9
通讯作者：
Pupek-Musialik, Danuta
中科院分区：
文献类型：
--
作者：
Suliburska, Joanna;Bogdanski, Pawe;Szulinska, Monika;Pupek-Musialik, Danuta
这项研究的目的是评估西布曲明对肥胖女性矿物质状态和选定的生化参数的影响。这项研究是在24名患者和20名接受安慰剂的患者身上进行的，这些患者每天服用15毫克的西布曲明，持续12周。在治疗6周和12周后，测量体重和血压，计算体重指数，并采集血样和第一次晨尿样本。测定血脂、血糖和一氧化氮水平。测定血清和尿样中铁(Fe)、铜(Cu)、锌(Zn)、钙(Ca)和镁(Mg)的含量。采用红细胞溶血法测定谷胱甘肽过氧化物酶(GSH-Px)和超氧化物歧化酶(SOD)活性。在研究过程中，没有观察到体重指数、血压或一氧化氮的变化。治疗12周后，观察到总胆固醇、低密度脂蛋白、甘油三酯、葡萄糖和铁蛋白水平下降。西布曲明治疗12周后，GSH-Px和SOD活性升高。治疗6周和12周后，血清镁、铜均有升高。12周后，血清锌水平下降。12周时尿中钙、镁、铁、锌、铜的排泄率也有所下降。服用安慰剂的女性没有发现差异。总之，我们发现西布曲明对肥胖女性的血脂和血糖状况有积极的影响。然而，这种药物扰乱了受试者体内的矿物质平衡，特别是锌和镁。
The aim of this study was to assess the effect of sibutramine on mineral status and selected biochemical parameters in obese women. The study was conducted on 24 patients who received 15 mg daily doses of sibutramine for 12 weeks, and on 20 patients who received placebo. At the baseline, after the sixth and twelfth weeks of treatment, body weight and blood pressure were measured, the BMI was calculated, and samples of blood and of first morning urine were collected. Serum lipid profiles, glucose levels, and nitric oxide levels were determined. The iron (Fe), copper (Cu), zinc (Zn), calcium (Ca), and magnesium (Mg) present in the serum and urine samples were assessed. The erythrocyte hemolysate of the patients was use to assay the activity of glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD). No changes were observed in BMI, blood pressure, or nitric oxide during the study. After 12 weeks of treatment, a decrease was observed in total cholesterol, LDL cholesterol, triglyceride, glucose, and ferritin levels. GSH-Px and SOD activity increased after 12 weeks of sibutramine treatment. The Mg and Cu increases was observed in serum after the sixth and twelfth weeks of treatment. It was found that the Zn level decreased in serum after the twelfth week. The elimination of Ca, Mg, Fe, Zn, and Cu in urine also declined in the twelfth week. No differences were found in the women taking the placebo. In conclusion, we found that sibutramine had a positive effect on lipid and glucose status in obese women. However, the drug disturbed the balance of minerals, especially Zn and Mg, in the subjects.
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DOI：
10.1001/jama.2010.1505
发表时间：
2010-10-27
期刊：
JAMA
影响因子：
--
作者：
Goodpaster BH;Delany JP;Otto AD;Kuller L;Vockley J;South-Paul JE;Thomas SB;Brown J;McTigue K;Hames KC;Lang W;Jakicic JM
通讯作者：
Jakicic JM
影响因子：
4.4
作者：
Naziroglu, Mustafa
通讯作者：
Naziroglu, Mustafa
影响因子：
3.9
作者：
Dastych, Milan;Prochazkova, Dagmar;Zdrazil, Libor
通讯作者：
Zdrazil, Libor
影响因子：
1.4
作者：
Lemos Júnior, Hernani Pinto de;Atallah, Álvaro Nagib;Lemos, André Luis Alves de
通讯作者：
Lemos, André Luis Alves de
影响因子：
1.2
作者：
Derosa, Giuseppe;Maffioli, Pamela;Cicero, Arrigo F. G.
通讯作者：
Cicero, Arrigo F. G.