Olig3 is not involved in the ventral patterning of spinal cord.
Olig3 is not involved in the ventral patterning of spinal cord.
复制标题
Olig3 不参与脊髓的腹侧模式。
DOI：
10.1371/journal.pone.0111076
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Qiu M
中科院分区：
文献类型：
--
作者：
Liu Z;Hu X;Huang C;Zheng K;Takebayashi H;Cao C;Qiu M
在胚胎阶段，Olig3最初在脊髓的背侧大部分区域表达，但后来也在腹侧边缘区表达。先前的研究表明，Olig3控制脊髓背侧的模式，Olig3功能的丧失导致dI2和dI3神经元重新规范为dI4中间神经元。然而，Olig3在调节腹侧脊髓发育中的作用尚不清楚。BrdU标记表明，腹侧Olig3在有丝分裂后的神经元中表达，胚胎晚期的Olig3+细胞在胚胎早期出生，但在整个胚胎发生过程中一直处于边缘区。功能丧失和功能获得实验表明，Nkx2.2调节V3中间神经元Olig3的表达。而Olig3突变对腹侧神经元的产生和迁移无明显影响。这些结果表明Olig3在调节脊髓背侧和腹侧发育中起着不同的作用。
At embryonic stages, Olig3 is initially expressed in the dorsal-most region of the spinal cord, but later in the ventral marginal zone as well. Previous studies indicated that Olig3 controlled the patterning of dorsal spinal cord and loss of Olig3 function led to the re-specification of dI2 and dI3 neurons into dI4 interneurons. However, the role of Olig3 in regulating the development of ventral spinal cord has remained unknown. BrdU labeling demonstrated that ventral Olig3 was expressed in the post-mitotic neurons and Olig3+ cells seen at late embryonic stages were born at the earlier stage but remained in the marginal zone throughout embryogenesis. Loss-of-function and gain-of-function experiment indicated that Nkx2.2 regulated the expression of Olig3 in V3 interneurons. However, Olig3 mutation didn’t apparently affect the generation and migration of ventral neurons. These findings suggest that Olig3 plays different roles in regulating the development of dorsal and ventral spinal cord.
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影响因子：
16.2
作者：
Lu, QR;Yuk, DI;Rowitch, DH
通讯作者：
Rowitch, DH
DOI：
10.1523/jneurosci.3769-08.2008
发表时间：
2008-10-01
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Liu Z;Li H;Hu X;Yu L;Liu H;Han R;Colella R;Mower GD;Chen Y;Qiu M
通讯作者：
Qiu M
影响因子：
16.2
作者：
Zhou, Q;Wang, SL;Anderson, DJ
通讯作者：
Anderson, DJ
影响因子：
3.7
作者：
Francius C;Harris A;Rucchin V;Hendricks TJ;Stam FJ;Barber M;Kurek D;Grosveld FG;Pierani A;Goulding M;Clotman F
通讯作者：
Clotman F
影响因子：
25
作者：
Cheng, LP;Arata, A;Ma, QF
通讯作者：
Ma, QF