The metabolic control of DNA replication: mechanism and function.
The metabolic control of DNA replication: mechanism and function.
复制标题
DOI：
10.1098/rsob.230220
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发表时间：
2023-08
期刊：
影响因子：
5.8
通讯作者：
Janniere, Laurent
中科院分区：
文献类型：
--
作者：
Soultanas, Panos;Janniere, Laurent
关键词：
新陈代谢和DNA复制是生命中两个最基本的生物学功能。代谢的分解代谢分支分解营养物以产生能量和前体，代谢的合成代谢分支使用所述能量和前体来合成大分子。DNA复制消耗能量和前体，忠实地复制基因组，将遗传物质一代一代地传播。我们对支撑和调节这两种生物功能的机制有着深刻的理解。然而，协调复制代谢的分子机制及其生物学功能仍然是未知的。了解生物体如何以及为什么通过细胞周期动态变化对波动的营养刺激做出反应，并在广泛的生长条件下可重复地和明显地使DNA合成时间化是重要的，对生命的所有领域都有更广泛的影响。在总结了开创性的研究，建立了复制的代谢控制的概念，我们回顾了从细菌到人类的复制代谢的数据。支持这些联系的分子见解，然后提出建议，复制的代谢控制使用的信号系统齿轮代谢组稳态编排复制时间。在该控制的突变体中发现的显着的复制表型突出了其在复制调节和潜在的遗传稳定性和肿瘤发生中的重要性。
Metabolism and DNA replication are the two most fundamental biological functions in life. The catabolic branch of metabolism breaks down nutrients to produce energy and precursors used by the anabolic branch of metabolism to synthesize macromolecules. DNA replication consumes energy and precursors for faithfully copying genomes, propagating the genetic material from generation to generation. We have exquisite understanding of the mechanisms that underpin and regulate these two biological functions. However, the molecular mechanism coordinating replication to metabolism and its biological function remains mostly unknown. Understanding how and why living organisms respond to fluctuating nutritional stimuli through cell-cycle dynamic changes and reproducibly and distinctly temporalize DNA synthesis in a wide-range of growth conditions is important, with wider implications across all domains of life. After summarizing the seminal studies that founded the concept of the metabolic control of replication, we review data linking metabolism to replication from bacteria to humans. Molecular insights underpinning these links are then presented to propose that the metabolic control of replication uses signalling systems gearing metabolome homeostasis to orchestrate replication temporalization. The remarkable replication phenotypes found in mutants of this control highlight its importance in replication regulation and potentially genetic stability and tumorigenesis.
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影响因子：
--
作者：
Burnell JN
通讯作者：
Burnell JN
影响因子：
20.8
作者：
Diener, Christian;Dai, Chengzhen L.;Wilmanski, Tomasz;Baloni, Priyanka;Smith, Brett;Rappaport, Noa;Hood, Leroy;Magis, Andrew T.;Gibbons, Sean M.
通讯作者：
Gibbons, Sean M.
影响因子：
7.7
作者：
Berge, Matthieu;Pezzatti, Julian;Viollier, Patrick H.
通讯作者：
Viollier, Patrick H.
DOI：
10.1083/jcb.85.1.96
发表时间：
1980-04
期刊：
The Journal of cell biology
影响因子：
--
作者：
Rivin CJ;Fangman WL
通讯作者：
Fangman WL
DOI：
10.1073/pnas.082112499
发表时间：
2002-04-30
影响因子：
11.1
作者：
Canback, B;Andersson, SGE;Kurland, CG
通讯作者：
Kurland, CG