Absolute cerebral blood flow: Assessment with a novel low-radiation-dose dynamic CT perfusion technique in a swine model.
Absolute cerebral blood flow: Assessment with a novel low-radiation-dose dynamic CT perfusion technique in a swine model.
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DOI：
10.1016/j.neurad.2021.09.003
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发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
Molloi S
中科院分区：
文献类型：
--
作者：
Abbona P;Zhao Y;Hubbard L;Malkasian S;Flynn B;Molloi S
采用荧光微球测量作为参考标准，在猪模型中验证新型低剂量动态CT灌注技术的准确性。对比增强动态CT灌注在五只猪在基线和脑栓塞后进行。以5 ml/s的速度注射参比微球和静脉造影剂（370 mg/ml碘，1 ml/kg），然后进行动态CT灌注。扫描参数为320×0.5 mm，100 kVp和200 mA。平均而言，每次采集47次对比增强体积扫描以捕获时间衰减曲线。对于每次采集，仅使用两个系统选择的体积扫描来用首过分析技术量化脑灌注。第一个体积扫描选择在底部，模拟团注跟踪，而第二个体积在时间衰减曲线的峰值，类似于CT血管造影。用t检验、线性回归和Bland-Altman分析比较区域低剂量CT灌注测量值与微球灌注测量值。确定双容积CT灌注技术的辐射剂量。低剂量CT灌注测量（PCT）显示与参考微球灌注测量（PMICRO）具有良好的相关性，PCT = 1.15 PMICRO - 0.01（r = 0.93，p ≤ 0.01）。双容积CT灌注技术的CT剂量指数和剂量长度乘积分别为25.6 mGy和409.6 mGy。在猪模型中验证了低剂量动态CT灌注技术的准确性和可重复性。该技术具有准确诊断和随访中风和血管痉挛的潜力。
To validate the accuracy of a novel low-dose dynamic CT perfusion technique in a swine model using fluorescent microsphere measurement as the reference standard. Contrast-enhanced dynamic CT perfusion was performed in five swine at baseline and following brain embolization. Reference microspheres and intravenous contrast (370 mg/ml iodine, 1 ml/kg) were injected (5 ml/s), followed by dynamic CT perfusion. Scan parameters were 320×0.5 mm, 100 kVp and 200 mA. On average, 47 contrast-enhanced volume scans were acquired per acquisition to capture the time attenuation curve. For each acquisition, only two systematically selected volume scans were used to quantify brain perfusion with first-pass analysis technique. The first volume scan was selected at the base, simulating bolus tracking, while the second volume at the peak of the time attenuation curve similar to a CT angiogram. Regional low-dose CT perfusion measurements were compared to the microsphere perfusion measurements with t-test, linear regression and Bland-Altman analysis. The radiation dose of the two-volume CT perfusion technique was determined. Low-dose CT perfusion measurements (PCT) showed excellent correlation with reference microsphere perfusion measurements (PMICRO) by PCT = 1.15 PMICRO - 0.01 (r = 0.93, p ≤ 0.01). The CT dose index and dose-length product for the two-volume CT perfusion technique were 25.6 mGy and 409.6 mGy, respectively. The accuracy and repeatability of a low-dose dynamic CT perfusion technique was validated in a swine model. This technique has the potential for accurate diagnosis and follow up of stroke and vasospasm.
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影响因子：
2.2
作者：
Bartoli, Carlo R.;Okabe, Kazunori;Godleski, John J.
通讯作者：
Godleski, John J.
影响因子：
19.7
作者：
Bivard, Andrew;Levi, Christopher;Parsons, Mark
通讯作者：
Parsons, Mark
影响因子：
4.8
作者：
Molloi, S;Zhou, YF;Kassab, GS
通讯作者：
Kassab, GS
DOI：
10.1097/rmr.0000000000000129
发表时间：
2017-06-01
期刊：
Topics in magnetic resonance imaging : TMRI
影响因子：
--
作者：
Krishnan, Pradeep;Murphy, Amanda;Aviv, Richard I
通讯作者：
Aviv, Richard I
影响因子：
37.8
作者：
Benjamin, Emelia J.;Virani, Salim S.;Muntner, Paul
通讯作者：
Muntner, Paul