Islet1-expressing cardiac progenitor cells: a comparison across species.

Islet1-expressing cardiac progenitor cells: a comparison across species.
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DOI:
10.1007/s00427-012-0400-1
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发表时间:
2013-03
影响因子:
2.4
通讯作者:
Kühl M
Kühl M
中科院分区:
生物学4区
文献类型:
--
作者:
Pandur P;Sirbu IO;Kühl SJ;Philipp M;Kühl M

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成年哺乳动物心脏干细胞表达LIM同源结构域转录因子Islet 1(Isl 1)。它们被认为是Isl 1阳性胚胎心脏祖细胞的残余。在心脏发育过程中,Isl 1阳性祖细胞主要产生流出道、右心室和部分心房。这导致了一个假设,即右心室的发育取决于额外的细胞募集到主要的心管。这些额外的Isl 1阳性细胞起源的区域被称为第二心脏区域,与第一心脏区域相反,第一心脏区域的细胞形成主要的心管。在这里,我们回顾了现有的数据Isl 1在不同的物种,表明Isl 1是一个重要组成部分的核心转录因子网络驱动早期心脏发生的动物的两个分支,后口动物,和原口动物。这些数据支持的观点,一个单一的心脏祖细胞群体,包括Isl 1表达细胞,并分化成各种心脏谱系在脊椎动物的胚胎发育过程中,但不是在其他门的动物王国。本文的在线版本(doi:10.1007/s 00427 -012-0400-1)包含补充材料,可供授权用户使用。
Adult mammalian cardiac stem cells express the LIM-homeodomain transcription factor Islet1 (Isl1). They are considered remnants of Isl1-positive embryonic cardiac progenitor cells. During amniote heart development, Isl1-positive progenitor cells give rise mainly to the outflow tract, the right ventricle, and parts of the atria. This led to the hypothesis that the development of the right ventricle of the amniote heart depends on the recruitment of additional cells to the primary heart tube. The region from which these additional, Isl1-positive cells originate is called second heart field, as opposed to the first heart field whose cells form the primary heart tube. Here, we review the available data about Isl1 in different species, demonstrating that Isl1 is an important component of the core transcription factor network driving early cardiogenesis in animals of the two clades, deuterostomes, and protostomes. The data support the view of a single cardiac progenitor cell population that includes Isl1-expressing cells and which differentiates into the various cardiac lineages during embryonic development in vertebrates but not in other phyla of the animal kingdom. The online version of this article (doi:10.1007/s00427-012-0400-1) contains supplementary material, which is available to authorized users.
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