Bacteria-triggered hyaluronan/AgNPs/gentamicin nanocarrier for synergistic bacteria disinfection and wound healing application
Bacteria-triggered hyaluronan/AgNPs/gentamicin nanocarrier for synergistic bacteria disinfection and wound healing application
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细菌触发的透明质酸/AgNPs/庆大霉素纳米载体用于协同细菌消毒和伤口愈合应用
DOI：
10.1016/j.cej.2019.122582
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发表时间：
2020-01
影响因子：
15.1
通讯作者：
Xiong Hua
中科院分区：
文献类型：
--
作者：
Yu Ningxiang;Wang Xiaoya;Qiu Liang;Cai Taimei;Jiang Chengjia;Sun Yong;Li Yanbin;Peng Hailong;Xiong Hua
在这里，我们报告了一种细菌触发的透明质酸/AgNPs/庆大霉素纳米载体（HB/Ag/g），具有高效的协同细菌消毒能力，当与贻贝启发的甲壳素水凝胶组合使用时，在伤口愈合中具有智能应用。简而言之，HB/Ag/g使用简单的自组装过程制备，并且表现出Ag和庆大霉素的可控释放，其由pH或从细菌释放的透明质酸酶（HAase）触发。从HB/Ag/g中释放的Ag和庆大霉素由于其不同的抗菌机制而显示出强大的协同抗菌活性。以HB/Ag/g为涂层块，采用浸渍干燥法在聚多巴胺改性甲壳素水凝胶（CPH）表面制备了消毒涂层，命名为HB/Ag/g@CPH。HB/Ag/g@CPH对细菌的生长和粘附有较强的抑制作用，对细胞的粘附和增殖无影响。最重要的是，体内结果表明HB/Ag/g@CPH可以方便地用于感染S的伤口的伤口消毒和加速伤口愈合。金黄色。
Here, we report on a bacteria-triggered hyaluronan/AgNPs/gentamicin nanocarrier (HB/Ag/g) that has highly efficient synergistic bacteria disinfection capability, and intelligent application in wound healing when used in combination with mussel-inspired chitin hydrogel. Briefly, HB/Ag/g was prepared using a simple self-assembly process and exhibited a controllable release of Ag and gentamicin that was triggered by either pH or hyaluronidase (HAase) which was released from bacteria. The Ag and gentamicin released from HB/Ag/g showed robust synergistic antibacterial activities because of their different antibacterial mechanisms. Furthermore, HB/Ag/g was used as a coating block for the construction of disinfectant coatings on polydopamine modified chitin hydrogel (CPH) by a facile dip-drying procedure, and the product was named HB/Ag/g@CPH. HB/Ag/g@CPH exhibited strong inhibition of the growth and adhesion of bacteria, and did not affect cell attachment and proliferation. Most importantly,in vivoresults indicate that HB/Ag/g@CPH can be conveniently used for wound disinfection and accelerated wound healing in a wound infected withS. aureus.
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影响因子：
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影响因子：
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