Increased Monocyte Chemotactic Protein-1 Accompanying Pro-Inflammatory Processes are Associated with Progressive Hearing Impairment and Bilateral Disability of Meniere’s Disease
Increased Monocyte Chemotactic Protein-1 Accompanying Pro-Inflammatory Processes are Associated with Progressive Hearing Impairment and Bilateral Disability of Meniere’s Disease
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伴随促炎症过程的单核细胞趋化蛋白 1 增加与梅尼埃病的进行性听力障碍和双侧残疾有关
DOI：
10.1159/000518839
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Ogawa Takenori
中科院分区：
文献类型：
--
作者：
Iinuma Ryota;Okuda Hiroshi;Obara Natsuko;Matsubara Yoshitaka;Aoki Mitsuhiro;Ogawa Takenori
背景梅尼埃病（Meniere 'sdisease，MD）听力损害的进展和双侧受累可能与病程和年龄有关。最近的研究报道，MD可能涉及由于炎症变化而损害的微血管循环功能障碍。目的本研究的目的是确定MD的听力障碍和双侧残疾的进展可能与几种促炎症过程的发病机制有关。（56.8±14.7岁）、7名双侧MD患者（65.3±13.9岁）和17名年龄匹配的对照受试者（53.5±14.4岁，p> 0.05）。检测血浆血管内皮生长因子（VEGF）、白细胞介素-6（IL-6）、肿瘤坏死因子α（TNFα）、结果双侧MD组和单侧MD组血浆MCP-1水平均高于正常对照组（P < 0. 05（204.7±41.0 pg/mL和169.5±32.0 pg/mL）高于对照组（149.2±30.7 pg/mL）（p< 0.05）。3组间血浆TNFα、IL-6、VEGF水平差异无统计学意义（P> 0.05）。MD患者血浆MCP-1水平与年龄呈显著正相关（r= 0.58，p< 0.01），而对照组血浆MCP-1水平与年龄无显著相关（p> 0.05）。健侧血浆MCP-1水平与500、1,000、2,000、4, 000 Hz的平均听力水平及冷热试验最大慢相眼速度显著相关（p< 0.05）。MD患者血浆MCP-1与IL-6（r= 0.49，p< 0.01）、TNFα（r= 0.32，p< 0.05）呈显著正相关。
BackgroundThe progression of hearing impairment and the bilateral involvement of Meniere’s disease (MD) may depend on the disease duration and aging. Recent studies reported that MD might involve dysfunction of the microvascular circulation damaged due to inflammatory changes.ObjectivesThe aim of this study was to determine that the progress of the MD’s hearing impairment and bilateral disability may be associated with the pathogenesis of several pro-inflammatory processes.Patients and MethodsWe recruited 30 unilateral MD patients (56.8±14.7 years old), 7 bilateral MD patients (65.3±13.9 years old), and 17 age-matched control subjects (53.5±14.4 years old, p> 0.05). We measured the plasma vascular endothelial growth factor (VEGF), plasma interleukin-6 (IL-6), plasma tumor-necrosis factor α (TNFα), and plasma monocyte chemotactic protein-1 (MCP-1).ResultsThe bilateral MD group and the unilateral MD group had higher plasma MCP-1 (204.7±41.0 pg/mL and 169.5±32.0 pg/mL) than the control group (149.2±30.7 pg/mL)(p< 0.05). There was no significant difference in plasma TNFα, IL-6, and VEGF among 3 groups (p> 0.05). There was a strong correlation between the plasma MCP-1 and age in MD patients (r= 0.58, p< 0.01); however, no significant correlation between the plasma MCP-1 and age was found in control subjects (p> 0.05). The plasma MCP-1 significantly correlated with the average hearing level of 500, 1,000, 2,000, and 4,000 Hz, and the maximum slow phase eye velocity in caloric test in the better side (p< 0.05). Also, the plasma MCP-1 showed significant positive correlations with the plasma IL-6 (r= 0.49, p< 0.01) and plasma TNFα (r= 0.32, p< 0.05) in MD group.ConclusionsOur results suggest that the increased plasma MCP-1 accompanying pro-inflammatory processes are associated with the progression of the hearing impairment and the bilateral disability of MD.
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作者：
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DOI：
10.1159/000276601
发表时间：
1994
期刊：
ORL; journal for oto-rhino-laryngology and its related specialties
影响因子：
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作者：
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影响因子：
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