Input-specific contributions to valence processing in the amygdala.
Input-specific contributions to valence processing in the amygdala.
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DOI：
10.1101/lm.037887.114
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发表时间：
2016-10
期刊：
影响因子：
--
通讯作者：
Goosens KA
中科院分区：
文献类型：
--
作者：
Correia SS;Goosens KA
奖励和惩罚通常被认为是相反的过程：奖励和预测它们的环境线索引发接近和完善行为，而惩罚则引发厌恶和回避行为。这一框架表明，这些有价值的行为可能存在分离的大脑回路。基底外侧杏仁核（BLA）是一个大脑区域，对这两种动机行为都有贡献。BLA中的单个神经元可以倾向于正价而不是负价，反之亦然，但这些神经元是混杂的，没有解剖上的分离。杏仁核接收来自大脑许多区域的输入，目前的理论认为，BLA神经元对正负价的编码是由每个神经元的线路决定的。具体地说，许多来自其他脑区的对正、负效刺激和预测线索作出反应的投射强烈地投射到脑区，并可能促进脑区内的价加工。在这里，我们回顾了三个区域，基底前脑，中缝背核和腹侧被盖区，并讨论了这些区域如何促进BLA内正负价的编码。
Reward and punishment are often thought of as opposing processes: rewards and the environmental cues that predict them elicit approach and consummatory behaviors, while punishments drive aversion and avoidance behaviors. This framework suggests that there may be segregated brain circuits for these valenced behaviors. The basolateral amygdala (BLA) is one brain region that contributes to both types of motivated behavior. Individual neurons in the BLA can favor positive over negative valence, or vice versa, but these neurons are intermingled, showing no anatomical segregation. The amygdala receives inputs from many brain areas and current theories posit that encoding of positive versus negative valence by BLA neurons is determined by the wiring of each neuron. Specifically, many projections from other brain areas that respond to positive and negative valence stimuli and predictive cues project strongly to the BLA and likely contribute to valence processing within the BLA. Here we review three of these areas, the basal forebrain, the dorsal raphe nucleus and the ventral tegmental area, and discuss how these may promote encoding of positive and negative valence within the BLA.
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