Marek's disease in chickens: a review with focus on immunology.
Marek's disease in chickens: a review with focus on immunology.
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DOI：
10.1186/s13567-016-0404-3
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发表时间：
2016-11-28
影响因子：
4.4
通讯作者：
Behboudi S
中科院分区：
文献类型：
--
作者：
Boodhoo N;Gurung A;Sharif S;Behboudi S
马立克氏病(Marek‘s disease，MD)是由马立克氏病病毒(Marek’s Disease Virus，MDV)引起的一种具有重要商业价值的禽类肿瘤性疾病，只能通过大规模接种疫苗来控制。重要的是，缺乏能够提供无菌免疫和抑制病毒传播的疫苗；因此，疫苗只能预防神经病、致癌性疾病和免疫抑制，而无法防止MDV的传播或感染，导致出现越来越强的致病类型。因此，为了解决这些问题，开发更有效的诱导无菌免疫的疫苗已成为当今禽类免疫学家的重要研究目标之一。MDV与大多数哺乳动物疱疹病毒如单纯疱疹病毒(HSV)具有非常相似的基因组功能和结构特征。MD还提供了一个很好的T细胞淋巴瘤模型，以深入了解其他疱疹病毒诱导的哺乳动物和鸟类的肿瘤发生。因此，我们需要对MD的宿主-病毒相互作用和宿主免疫有深入的了解和理解。同样，不同鸡品系的潜在遗传变异对感染结果有重大影响。在这篇综述文章中，我们旨在探讨MDV感染的发病机制，宿主对MD的免疫，并讨论需要进一步探索的研究领域。
Marek’s disease (MD), caused by Marek’s disease virus (MDV), is a commercially important neoplastic disease of poultry which is only controlled by mass vaccination. Importantly, vaccines that can provide sterile immunity and inhibit virus transmission are lacking; such that vaccines are only capable of preventing neuropathy, oncogenic disease and immunosuppression, but are unable to prevent MDV transmission or infection, leading to emergence of increasingly virulent pathotypes. Hence, to address these issues, developing more efficacious vaccines that induce sterile immunity have become one of the important research goals for avian immunologists today. MDV shares very close genomic functional and structural characteristics to most mammalian herpes viruses such as herpes simplex virus (HSV). MD also provides an excellent T cell lymphoma model for gaining insights into other herpesvirus-induced oncogenesis in mammals and birds. For these reasons, we need to develop an in-depth knowledge and understanding of the host-viral interaction and host immunity against MD. Similarly, the underlying genetic variation within different chicken lines has a major impact on the outcome of infection. In this review article, we aim to investigate the pathogenesis of MDV infection, host immunity to MD and discuss areas of research that need to be further explored.
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