How hypoxia slows fetal growth: insights from high altitude.
How hypoxia slows fetal growth: insights from high altitude.
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DOI：
10.1038/s41390-021-01784-0
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发表时间：
2022-01
影响因子：
3.6
通讯作者：
Moore LG
中科院分区：
文献类型：
--
作者：
Moore LG
持续的氧气供应对于促进胎儿生长至关重要，但令人惊讶的是，我们对缺氧降低胎儿生长的确切机制知之甚少。动物模型虽然很重要，但受到哺乳动物对怀孕的生理反应的巨大变异性的限制。了解缺氧引起的胎儿生长减少的最早模型之一来自高海拔地区的研究，该研究表明高海拔地区对胎儿生长具有最强的抑制作用之一。但并非所有人群都受到同样的影响。卓玛等人现在添加了有价值的信息，表明拉达克人与藏人和安第斯人一样，小于胎龄 (SGA) 婴儿的频率低于预期。与之前的报道一致，这些作者还发现，在高海拔地区，产下适龄孕龄 (AGA) 的女性在妊娠中期（第 26-28 周）的子宫动脉直径大于 SGA 婴儿，但有趣的是，在低海拔地区则不然。关于缺氧损害胎儿生长的生理途径还有很多东西有待了解。高海拔地区人群的差异性以及研究因果机制的工具日益复杂化，有可能扩大我们目前有限的手段，以确定妊娠和胎儿生命中缺氧相关并发症的新治疗方法。
A continuous oxygen supply is vital for fueling fetal growth, yet we know surprisingly little as to the precise mechanisms by which hypoxia reduces fetal growth. Animal models, while important, are limited by the enormous variability in mammalian physiologic responses to pregnancy. One of the earliest models for understanding hypoxia-induced reductions in fetal growth came from studies at high altitude that showed high altitude to have one of the strongest depressant effects on fetal growth. But all populations are not equally affected. Dolma et al., have added valuable information now showing that that Ladakhis, like Tibetans and Andeans, have a lower-than-expected frequency of small-for-gestational age (SGA) infants. Consistent with previous reports, these authors also found that uterine artery diameters at mid pregnancy (week 26–28) were larger in women giving birth to appropriate-for-gestational-age (AGA) than SGA infants at high but, interestingly, not at low altitude. Much remains to be learned about the physiologic pathways by which hypoxia impairs fetal growth. The variability among high-altitude populations and increasing sophistication of tools for investigating causal mechanisms have the potential to expand our presently limited means for identifying new treatments for hypoxia-related complications of pregnancy and fetal life.
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DOI：
10.1111/j.1471-0528.1992.tb13818.x
发表时间：
1992-07-01
期刊：
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY
影响因子：
--
作者：
DULEY, L
通讯作者：
DULEY, L
影响因子：
2.9
作者：
Hale, Sarah A.;Jones, Cresta W.;Bernstein, Ira M.
通讯作者：
Bernstein, Ira M.
影响因子：
8.3
作者：
Lorca, Ramon A.;Lane, Sydney L.;Moore, Lorna G.
通讯作者：
Moore, Lorna G.
影响因子：
120.7
作者：
UNGER, C;WEISER, JK;MOORE, LG
通讯作者：
MOORE, LG
影响因子：
13.8
作者：
Pels, Anouk;Derks, Jan;Ganzevoort, Wessel
通讯作者：
Ganzevoort, Wessel