Structural and functional connectivity of the human brain in autism spectrum disorders and attention-deficit/hyperactivity disorder: A rich club-organization study.
Structural and functional connectivity of the human brain in autism spectrum disorders and attention-deficit/hyperactivity disorder: A rich club-organization study.
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DOI：
10.1002/hbm.22603
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发表时间：
2014-12
影响因子：
4.8
通讯作者：
Fair, Damien A.
中科院分区：
文献类型：
--
作者：
Ray, Siddharth;Miller, Meghan;Karalunas, Sarah;Robertson, Charles;Grayson, David S.;Cary, Robert P.;Hawkey, Elizabeth;Painter, Julia G.;Kriz, Daniel;Fombonne, Eric;Nigg, Joel T.;Fair, Damien A.
关键词：
注意缺陷多动障碍（ADHD）和自闭症谱系障碍（ASD）是儿童中最常见和最令人烦恼的两种神经发育障碍。虽然这两种疾病有许多共同的行为和神经心理学特征，但大多数MRI研究一次只检查其中一种疾病。使用图论结合结构和功能连接，我们研究了三组儿童之间的大规模网络组织：ADHD组（8-12岁，n = 20），ASD组（7-13岁，n = 16）和典型发展对照组（TD）（8-12岁，n = 20）。我们采用富人俱乐部组织的概念，即中心的、高度连接的枢纽地区也高度连接到自己。我们将大脑分为两个不同的网络域：（1）富人俱乐部网络内的现象，（2）富人俱乐部网络外的现象。ASD和ADHD人群的丰富俱乐部和非丰富俱乐部连接的功能和结构数据有显着不同的模式。ASD组在结构和功能网络中表现出更高的连通性，但仅在富人俱乐部网络中。使用自闭症脑成像数据交换（ABIDE）数据集与ASD（n = 85）和TD（n = 101）复制这些发现。ADHD组表现出较低的广义分数各向异性（GFA）和丰富的俱乐部网络内的功能连接，但丰富的俱乐部外的轴突纤维和相关系数值较高。尽管有一些共同的生物学特征和频繁的合并症，这些数据表明ADHD和ASD在童年中期表现出不同的大规模连接模式。
Attention deficit hyperactive disorder (ADHD) and Autism spectrum disorders (ASD) are two of the most common and vexing neurodevelopmental disorders among children. Although the two disorders share many behavioral and neuropsychological characteristics, most MRI studies examine only one of the disorders at a time. Using graph theory combined with structural and functional connectivity, we examined the large-scale network organization among three groups of children: a group with ADHD (8-12 years, n = 20), a group with ASD (7-13 years, n = 16), and typically developing controls (TD) (8-12 years, n = 20). We apply the concept of the rich-club organization, whereby central, highly connected hub regions are also highly connected to themselves. We examine the brain into two different network domains: (1) inside a rich-club network phenomena, and (2) outside a rich-club network phenomena. ASD and ADHD populations had markedly different patterns of rich club and non rich-club connections in both functional and structural data. The ASD group exhibited higher connectivity in structural and functional networks but only inside the rich-club networks. These findings were replicated using the autism brain imaging data exchange (ABIDE) dataset with ASD (n = 85) and TD (n = 101). The ADHD group exhibited a lower generalized fractional anisotropy (GFA) and functional connectivity inside the rich-club networks, but a higher number of axonal fibers and correlation coefficient values outside the rich-club. Despite some shared biological features and frequent comorbity, these data suggest ADHD and ASD exhibit distinct large-scale connectivity patterns in middle childhood.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
10.6
作者：
Fair, Damien A.;Posner, Jonathan;Nagel, Bonnie J.;Bathula, Deepti;Dias, Taciana G. Costa;Mills, Kathryn L.;Blythe, Michael S.;Giwa, Aishat;Schmitt, Colleen F.;Nigg, Joel T.
通讯作者：
Nigg, Joel T.
影响因子：
3
作者：
Hagmann P;Grant PE;Fair DA
通讯作者：
Fair DA
影响因子：
11
作者：
Di Martino, A.;Yan, C-G;Li, Q.;Denio, E.;Castellanos, F. X.;Alaerts, K.;Anderson, J. S.;Assaf, M.;Bookheimer, S. Y.;Dapretto, M.;Deen, B.;Delmonte, S.;Dinstein, I.;Ertl-Wagner, B.;Fair, D. A.;Gallagher, L.;Kennedy, D. P.;Keown, C. L.;Keysers, C.;Lainhart, J. E.;Lord, C.;Luna, B.;Menon, V.;Minshew, N. J.;Monk, C. S.;Mueller, S.;Mueller, R. A.;Nebel, M. B.;Nigg, J. T.;O'Hearn, K.;Pelphrey, K. A.;Peltier, S. J.;Rudie, J. D.;Sunaert, S.;Thioux, M.;Tyszka, J. M.;Uddin, L. Q.;Verhoeven, J. S.;Wenderoth, N.;Wiggins, J. L.;Mostofsky, S. H.;Milham, M. P.
通讯作者：
Milham, M. P.
影响因子：
14.5
作者：
Gotts, Stephen J.;Simmons, W. Kyle;Martin, Alex
通讯作者：
Martin, Alex