Olfactory function and disease severity in chronic rhinosinusitis.
Olfactory function and disease severity in chronic rhinosinusitis.
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DOI：
10.2500/ajra.2009.23.3286
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发表时间：
2009-03
影响因子：
2.6
通讯作者：
Smith TL
中科院分区：
文献类型：
--
作者：
Litvack JR;Mace JC;Smith TL
嗅觉功能障碍被认为是导致生活质量（QOL）不佳的一个重要因素。然而，对于慢性鼻窦炎（CRS）患者的嗅觉测试与其他疾病负担指标的关系知之甚少。在这项研究中，我们研究了 CRS 患者的嗅觉功能与计算机断层扫描 (CT) 评分、内窥镜检查评分和生活质量测量的关系。对 367 名患者进行了多机构横断面分析。收集了多项客观指标：气味识别测试、Lund-MacKay CT 评分、Lund-Kennedy 内窥镜评分、两种经过验证的疾病特异性 QOL 工具（鼻窦炎残疾指数和慢性鼻窦炎调查）以及一般健康相关 QOL 工具（Medical Short Form-36）。进行方差分析。计算相关系数。嗅觉功能障碍患者的平均内窥镜评分显着较差（嗅觉正常：4.16 (± 3.97)；嗅觉减退：6.26 (± 4.21)；嗅觉缺失：9.61 (± 4.48)；p<0.001），CT 评分显着较差（嗅觉正常：9.11 (± 5.40)；嗅觉减退：11.16 (± 5.96）；嗅觉缺失：17.62 (± 5.37)； p<0.001）。内窥镜检查评分与嗅觉评分中度相关（r= -0.46，95% CI -0.38，-0.54；p<0.001）。 CT 评分与嗅觉评分中度相关（r= -0.53，95% CI -0.45，-0.60；p<0.001）。嗅觉功能与疾病特异性或一般健康相关的生活质量测量不相关。尽管之前的研究表明嗅觉障碍与生活质量差有关，但本研究发现没有这种相关性。相比之下，嗅觉评分与 CRS 的其他客观指标（即内窥镜检查和 CT 评分）密切相关。
Olfactory dysfunction is deemed to be a significant contributor to poor quality of life (QOL). However, little is known about the relationship of olfactory testing to other measures of disease burden in patients with chronic rhinosinusitis (CRS). In this study, we examine the relationship of olfactory function to computed tomography (CT) scores, endoscopy scores, and QOL measures in patients with CRS. A multi-institutional, cross-sectional analysis of 367 patients was performed. Several objective measures were collected: the Smell Identification Test, Lund-MacKay CT score, Lund-Kennedy endoscopy score, two validated disease-specific QOL instruments, the Rhinosinusitis Disability Index and the Chronic Sinusitis Survey, and a general health-related QOL instrument, the Medical Short Form-36. Analysis of variance was performed. Correlation coefficients were calculated. Patients with olfactory dysfunction had significantly worse mean endoscopy scores (normosmics: 4.16 (± 3.97); hyposmics: 6.26 (± 4.21); anosmics: 9.61 (± 4.48); p<0.001) and significantly worse CT scores (normosmics: 9.11 (± 5.40); hyposmics: 11.16 (± 5.96); anosmics: 17.62 (± 5.37); p<0.001). Endoscopy scores were moderately correlated with olfactory scores (r= -0.46, 95% CI -0.38, -0.54; p<0.001). CT scores were moderately correlated with olfactory scores (r= -0.53, 95% CI -0.45, -0.60; p<0.001). Olfactory function was not correlated with disease-specific or general health-related QOL measures. Although previous studies have suggested that olfactory impairment is associated with poor QOL, this study found no such correlation. In contrast, olfaction scores correlated well with other objective measures of CRS, namely endoscopy and CT scores.
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影响因子：
3.4
作者：
Piccirillo, JF;Merritt, MG;Richards, ML
通讯作者：
Richards, ML
DOI：
10.1177/194589240301700106
发表时间：
2003-01-01
期刊：
AMERICAN JOURNAL OF RHINOLOGY
影响因子：
--
作者：
Bhattacharyya, N
通讯作者：
Bhattacharyya, N
影响因子：
3.5
作者：
Doty, RL;McKeown, DA;Shaman, P
通讯作者：
Shaman, P
影响因子：
2.6
作者：
GLIKLICH, RE;METSON, R
通讯作者：
METSON, R
影响因子：
2.9
作者：
DOTY, RL;SHAMAN, P;DANN, M
通讯作者：
DANN, M