Strong hybrid male incompatibilities impede the spread of a selfish chromosome between populations of a fly.
Strong hybrid male incompatibilities impede the spread of a selfish chromosome between populations of a fly.
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DOI：
10.1002/evl3.55
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发表时间：
2018-06
影响因子：
5
通讯作者：
Price TAR
中科院分区：
文献类型：
--
作者：
Verspoor RL;Smith JML;Mannion NLM;Hurst GDD;Price TAR
减数分裂驱动的性染色体操纵配子发生，以增加其传输的代价，其余的基因组。它们产生的基因组内冲突对其宿主物种的生态和进化产生重大影响。然而，对它们的生态动态仍然知之甚少。简单的种群遗传模型预测减数分裂驱动因子将迅速在种群中固定并在景观中传播。与此相反，自然种群通常表现出空间变异的频率的驱动程序，与驱动器存在于渐变或马赛克跨越物种范围。例如，果蝇subobscura在北非以15-25%的频率携带性比扭曲驱动染色体（SR），在邻近的西班牙南部以低于2%的频率存在，并且在其他欧洲种群中不存在。在这里，我们调查的力量，防止司机向北蔓延。我们发现，SR一直保持在一个恒定的频率在北非，并未能在西班牙蔓延。我们发现了强有力的证据表明，传播是由遗传不相容的SR和西班牙常染色体背景。当我们从北非到西班牙的遗传背景交叉SR，我们观察到强烈的不相容性，具体到杂交轴承SR。在F2雄性杂种中，不相容性的严重程度增加，导致几乎完全不育。我们发现没有证据支持另一种假设，即有阻力驱动器在西班牙人口。我们的结论是阶梯频率变化的来源是SRs染色体和相邻群体的遗传背景之间的遗传不相容性，阻止SRs向北传播。在西班牙南部的低频率的SR是一致的经常性的基因流横跨直布罗陀海峡结合对SR元件通过遗传不相容性的选择。这表明，驱力染色体和原始种群之间的不相容性可以阻止驱力在大陆范围内在种群之间的传播。
Meiotically driving sex chromosomes manipulate gametogenesis to increase their transmission at a cost to the rest of the genome. The intragenomic conflicts they produce have major impacts on the ecology and evolution of their host species. However, their ecological dynamics remain poorly understood. Simple population genetic models predict meiotic drivers will rapidly reach fixation in populations and spread across landscapes. In contrast, natural populations commonly show spatial variation in the frequency of drivers, with drive present in clines or mosaics across species ranges. For example, Drosophila subobscura harbors a sex ratio distorting drive chromosome (SRs) at 15–25% frequency in North Africa, present at less than 2% frequency in adjacent southern Spain, and absent in other European populations. Here, we investigate the forces preventing the spread of the driver northward. We show that SRs has remained at a constant frequency in North Africa, and failed to spread in Spain. We find strong evidence that spread is impeded by genetic incompatibility between SRs and Spanish autosomal backgrounds. When we cross SRs from North Africa onto Spanish genetic backgrounds we observe strong incompatibilities specific to hybrids bearing SRs. The incompatibilities increase in severity in F2 male hybrids, leading to almost complete infertility. We find no evidence supporting an alternative hypothesis, that there is resistance to drive in Spanish populations. We conclude that the source of the stepped frequency variation is genetic incompatibility between the SRs chromosome and the genetic backgrounds of the adjacent population, preventing SRs spreading northward. The low frequency of SRs in South Spain is consistent with recurrent gene flow across the Strait of Gibraltar combined with selection against the SRs element through genetic incompatibility. This demonstrates that incompatibilities between drive chromosomes and naïve populations can prevent the spread of drive between populations, at a continental scale.
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影响因子：
10.7
作者：
Bastide, Heloise;Cazemajor, Michel;Montchamp-Moreau, Catherine
通讯作者：
Montchamp-Moreau, Catherine
一妻多夫制和野生家鼠种群中自私遗传因素的减少。
DOI：
10.1111/j.1558-5646.2011.01336.x
发表时间：
2011-09
期刊：
Evolution; international journal of organic evolution
影响因子：
--
作者：
Manser A;Lindholm AK;König B;Bagheri HC
通讯作者：
Bagheri HC
影响因子：
16.8
作者：
Meiklejohn, Colin D.;Tao, Yun
通讯作者：
Tao, Yun
影响因子：
3.3
作者：
FRANK, SA
通讯作者：
FRANK, SA
影响因子：
3.3
作者：
Holman, Luke;Freckleton, Robert P.;Snook, Rhonda R.
通讯作者：
Snook, Rhonda R.