Non-noxious skin stimulation activates the nucleus basalis of Meynert and promotes NGF secretion in the parietal cortex via nicotinic ACh receptors.
Non-noxious skin stimulation activates the nucleus basalis of Meynert and promotes NGF secretion in the parietal cortex via nicotinic ACh receptors.
复制标题
DOI：
10.1007/s12576-014-0313-z
复制
发表时间：
2014-07
影响因子：
2.3
通讯作者：
Uchida, Sae
中科院分区：
文献类型：
--
作者：
Hotta, Harumi;Watanabe, Nobuhiro;Piche, Mathieu;Hara, Sanae;Yokawa, Takashi;Uchida, Sae
关键词：
观察非伤害性皮肤刺激对麻醉大鼠顶叶皮质神经生长因子(NGF)分泌的影响。用柔软的毛刷对左后肢进行无害的皮肤刺激。用蛋白质透过性探针通过微透析法收集右侧顶叶皮质的细胞外NGF，并用酶联免疫吸附分析法检测。刷牙导致细胞外NGF水平显著增加。在用烟碱型ACh受体(NAChR)拮抗剂甲乙胺预处理的大鼠中，未观察到这种NGF反应。通过功能磁共振成像进一步观察刷牙能否激活大脑皮质胆碱能纤维的主要来源--基底前脑核(NBM)。在刷牙过程中，右侧NBM的血氧水平依赖信号显著高于基线。结果提示，非伤害性皮肤刺激通过nAChRs激活NBM，促进顶叶皮质NGF的分泌。
The effects of non-noxious skin stimulation on nerve growth factor (NGF) secretion in the parietal cortex were examined in anesthetized rats. Innocuous skin stimulation was delivered to the left hindlimb with a soft-hair brush. Extracellular NGF in the right parietal cortex was collected by microdialysis methods using a protein-permeable probe and was measured using an enzyme-linked immune-sorbent assay. Brushing produced a significant increase in extracellular NGF levels. This NGF response was not observed in rats pretreated with a nicotinic ACh receptor (nAChR) antagonist mecamylamine. We further examined whether brushing could activate the basal forebrain nucleus (nucleus basalis of Meynert, NBM), which is the main source of cholinergic fibers in the cerebral cortex, by means of functional MRI. The blood oxygen level-dependent signal in the right NBM was significantly higher during brushing compared to baseline. The results suggest that non-noxious skin stimulation activates NBM and promotes NGF secretion in the parietal cortex via nAChRs.
登录
查看更多内容
影响因子：
4.2
作者：
KUROSAWA, M;SATO, A;SATO, Y
通讯作者：
SATO, Y
DOI：
10.1016/j.apmr.2008.03.016
发表时间：
2008-10-01
影响因子：
4.3
作者：
Hunter, Susan M.;Crome, Peter;Pomeroy, Valerie M.
通讯作者：
Pomeroy, Valerie M.
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
2.5
作者：
BASKERVILLE, KA;CHANG, HT;HERRON, P
通讯作者：
HERRON, P
影响因子：
1.9
作者：
Kawahira, Kazumi;Shimodozono, Megumi;Tanaka, Nobuyuki
通讯作者：
Tanaka, Nobuyuki