Hematopoietic stem cell transplantation for leukemia.
Hematopoietic stem cell transplantation for leukemia.
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DOI:
10.1016/j.pcl.2009.11.005
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发表时间:
2010-02
影响因子:
2.6
通讯作者:
Egeler, R. Maarten
中科院分区:
文献类型:
--
作者:
Wayne, Alan S.;Baird, Kristin;Egeler, R. Maarten
Leukemia represents the most common pediatric malignancy, accounting for approximately 30% of all cancers in children less than 20 years of age. Acute lymphoblastic leukemia (ALL) is the most frequent, comprising approximately 23% of childhood cancers. Acute myeloid leukemia (AML) accounts for approximately 4% of pediatric cancer diagnoses and 20% of childhood leukemia. Chronic myelogenous leukemia (CML) is rare and accounts for approximately 1% of all pediatric cancer, although it comprises 10% of leukemia in older adolescents. Juvenile myelomonocytic leukemia (JMML) is infrequent making up about 2% of leukemia and 25% of myelodysplastic syndrome in childhood [1]. Most children diagnosed with leukemia are cured without hematopoietic stem cell transplantation (HSCT), but for some, high-risk subgroups, allogeneic HSCT plays an important role in their therapeutic approach.
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