Hematopoietic stem cell transplantation for leukemia.

Hematopoietic stem cell transplantation for leukemia.
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DOI:
10.1016/j.pcl.2009.11.005
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发表时间:
2010-02
影响因子:
2.6
通讯作者:
Egeler, R. Maarten
Egeler, R. Maarten
中科院分区:
医学3区
文献类型:
--
作者:
Wayne, Alan S.;Baird, Kristin;Egeler, R. Maarten

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白血病是最常见的儿科恶性肿瘤,约占20岁以下儿童所有癌症的30%。急性淋巴细胞白血病(ALL)是最常见的,约占儿童癌症的23%。急性髓性白血病(AML)约占儿科癌症诊断的4%和儿童白血病的20%。慢性粒细胞性白血病(CML)是罕见的,约占所有儿科癌症的1%,尽管它占大龄青少年白血病的10%。幼年粒单核细胞白血病(JMML)是罕见的,约占儿童白血病的2%和骨髓增生异常综合征的25%[1]。大多数诊断为白血病的儿童在没有造血干细胞移植(HSCT)的情况下治愈,但对于一些高危亚组,异基因HSCT在其治疗方法中起着重要作用。
Leukemia represents the most common pediatric malignancy, accounting for approximately 30% of all cancers in children less than 20 years of age. Acute lymphoblastic leukemia (ALL) is the most frequent, comprising approximately 23% of childhood cancers. Acute myeloid leukemia (AML) accounts for approximately 4% of pediatric cancer diagnoses and 20% of childhood leukemia. Chronic myelogenous leukemia (CML) is rare and accounts for approximately 1% of all pediatric cancer, although it comprises 10% of leukemia in older adolescents. Juvenile myelomonocytic leukemia (JMML) is infrequent making up about 2% of leukemia and 25% of myelodysplastic syndrome in childhood [1]. Most children diagnosed with leukemia are cured without hematopoietic stem cell transplantation (HSCT), but for some, high-risk subgroups, allogeneic HSCT plays an important role in their therapeutic approach.
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