Challenging dogmas: How transgenerational epigenetics reshapes our views on life.
Challenging dogmas: How transgenerational epigenetics reshapes our views on life.
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DOI：
10.1002/jez.2465
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发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
Allard P
中科院分区：
文献类型：
--
作者：
Wang HD;Allard P
跨代表观遗传学（TEI）领域的出现深刻地重塑了我们对环境、索马和生殖细胞以及遗传之间关系的理解。TEI是指染色质状态、基因表达和/或表型的变化，这些变化在几代人之间传递，而不涉及DNA序列的变化。TEI与分子生物学、遗传学、发育生物学和生殖生物学等领域有直接联系，并从中汲取营养。然而，TEI相关研究的扩展深刻地重塑了每个领域的边界，并经常导致被认为是生物学原则的理论和概念的侵蚀。我们首先探讨了生物学的分子化如何改变了表观遗传学的定义，使其包括遗传的概念，以及表观遗传学如何完善了我们对生物学中心法则的理解。环境信息通过细胞外囊泡从索马转移到生殖细胞，并随后改变后代的健康结果，这一事实明确地结束了长期坚持的魏斯曼屏障原则。TEI还同时导致了后天特征遗传的复兴，同时进一步削弱了哺乳动物表观遗传“白板”的概念。使用一个历史框架，并通过在该领域的中心研究的探索，在这篇透视文章中，我们将得出一个令人信服的论据，TEI在生物学中的革命性方面。
The emergence of the field of Transgenerational Epigenetics Inheritance (TEI) has profoundly reshaped our understanding of the relationships between environment, soma, and germ cells as well as of heredity. TEI refers to the changes in chromatin state, gene expression, and/or phenotypes that are transmitted across several generations without involving changes to the DNA sequences. TEI has direct connections with, and feeds from, the fields of molecular biology, genetics, developmental biology, and reproductive biology, among others. However, the expansion of TEI-related research, has profoundly reshaped boundaries within each field and often led to the erosion of theories and concepts considered as tenets of biology. We first explore how the molecularization of biology has shifted the definition of epigenetics to include the notion of heredity and how epigenetics has refined our understanding of the central dogma of biology. The demonstrated transfer of environmental information from soma to germ cell through extra-cellular vesicles and subsequent alteration of health outcomes in offspring has put a definite end to the long-held principle of the Weismann barrier. TEI has also simultaneously led to the revival of the inheritance of acquired characteristics while further eroding the concept of an epigenetic “blank slate” in mammals. Using an historical framework, and via the exploration of central studies in the field, in this perspective article, we will draw a compelling argument for the revolutionary aspect of TEI in biology.
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影响因子：
20.1
作者：
Gillette TG;Hill JA
通讯作者：
Hill JA
影响因子：
29
作者：
Sharma U;Rando OJ
通讯作者：
Rando OJ
影响因子：
64.8
作者：
CRICK, F
通讯作者：
CRICK, F
DOI：
10.1126/science.1237973
发表时间：
2013-08-16
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Engreitz JM;Pandya-Jones A;McDonel P;Shishkin A;Sirokman K;Surka C;Kadri S;Xing J;Goren A;Lander ES;Plath K;Guttman M
通讯作者：
Guttman M
影响因子：
56.9
作者：
Reinhart, BJ;Bartel, DP
通讯作者：
Bartel, DP