Genetic polymorphisms in estrogen-related genes and the risk of breast cancer among Han Chinese women.
Genetic polymorphisms in estrogen-related genes and the risk of breast cancer among Han Chinese women.
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中国汉族女性雌激素相关基因多态性与乳腺癌风险
DOI：
10.3390/ijms16024121
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发表时间：
2015-02-13
影响因子：
5.6
通讯作者：
Yang XX
中科院分区：
文献类型：
--
作者：
Sun MY;Du HY;Zhu AN;Liang HY;de Garibay GR;Li FX;Li M;Yang XX
暴露于高水平的雌激素被认为是乳腺癌易感性的重要风险因素。影响雌激素水平的常见基因多态可能与乳腺癌风险有关，但尚未在中国汉族女性中进行全面研究。本研究利用Massarray IPLEX平台对1076名汉族女性雌激素相关基因的32个单核苷酸多态(SNPs)进行了基因分型。比较病例组和对照组的基因频率和等位基因频率。采用非条件Logistic回归分析SNPs对乳腺癌风险的影响。根据雌激素受体(ER)和孕激素受体(PR)状态对乳腺癌亚型的相关性也进行了评估。病例对照分析显示，rs700519和rs2069522杂合子与乳腺癌的危险性显著相关(OR=0.723，95%CI=0.541~0.965，p=0.028和OR=1.500，95%CI=1.078~2.087，p=0.016)。亚组比较显示rs2446405和rs17268974与ER状态相关，rs130021与PR状态相关。我们的发现表明，rs700519和rs2069522与中国汉族人群乳腺癌的易感性有关，并与其他三个已发现的SNPs有累积效应。需要进一步的遗传和功能研究来确定更多的SNPs，并阐明潜在的分子机制。
Exposure to high levels of estrogen is considered an important risk factor for susceptibility to breast cancer. Common polymorphisms in genes that affect estrogen levels may be associated with breast cancer risk, but no comprehensive study has been performed among Han Chinese women. In the present study, 32 single-nucleotide polymorphisms (SNPs) in estrogen-related genes were genotyped using the MassARRAY IPLEX platform in 1076 Han Chinese women. Genotypic and allelic frequencies were compared between case and control groups. Unconditional logistic regression was used to assess the effects of SNPs on breast cancer risk. Associations were also evaluated for breast cancer subtypes stratified by estrogen receptor (ER) and progesterone receptor (PR) status. Case-control analysis showed a significant relation between heterozygous genotypes of rs700519 and rs2069522 and breast cancer risk (OR = 0.723, 95% CI = 0.541–0.965, p = 0.028 and OR = 1.500, 95% CI = 1.078–2.087, p = 0.016, respectively). Subgroup comparisons revealed that rs2446405 and rs17268974 were related to ER status, and rs130021 was associated with PR status. Our findings suggest that rs700519 and rs2069522 are associated with susceptibility to breast cancer among the Han Chinese population and have a cumulative effect with three other identified SNPs. Further genetic and functional studies are needed to identify additional SNPs, and to elucidate the underlying molecular mechanisms.
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TOX3/LOC643714 中的 5 个 SNP 与中国南方乳腺癌的风险关联
影响因子：
5.6
作者：
He X;Yao G;Li F;Li M;Yang X
通讯作者：
Yang X
DOI：
10.1186/bcr921
发表时间：
2004
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Hankinson SE;Colditz GA;Willett WC
通讯作者：
Willett WC
影响因子：
3.8
作者：
Ma, Xiangyu;Qi, Xiaowei;Jiang, Jun
通讯作者：
Jiang, Jun
影响因子：
6.6
作者：
Liyanarachchi, Sandya;Wojcicka, Anna;de la Chapelle, Albert
通讯作者：
de la Chapelle, Albert
影响因子：
--
作者：
Li, Kai;Li, Wusheng;Zou, Huawei
通讯作者：
Zou, Huawei