Role and species-specific expression of colon T cell homing receptor GPR15 in colitis.
Role and species-specific expression of colon T cell homing receptor GPR15 in colitis.
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作者：
淋巴细胞募集维持肠道免疫稳态，但也有助于炎症。孤儿趋化因子受体GPR 15介导小鼠结肠中的调节性T细胞归巢和免疫抑制。我们表明，GPR 15也表达的小鼠TH 17和TH 1效应细胞，并需要结肠炎的模型，这取决于他们的贩运到结肠。在人类中，GPR 15由效应细胞表达，包括溃疡性结肠炎中的致病性TH 2细胞，但不由调节性T（Treg）细胞表达。TH 2转录激活因子加塔-3和Treg相关转录抑制因子FOXP 3与人而非小鼠的GPR 15增强子序列牢固结合，与表达相关。我们的研究结果突出了GPR 15调控的物种差异，并表明它是结肠炎的潜在治疗靶点。
Lymphocyte recruitment maintains intestinal immune homeostasis but also contributes to inflammation. The orphan chemoattractant receptor GPR15 mediates regulatory T cell homing and immunosuppression in the mouse colon. We show that GPR15 is also expressed by mouse TH17 and TH1 effector cells, and is required for colitis in a model that depends on their trafficking to the colon. In humans GPR15 is expressed by effector cells including pathogenic TH2 cells in ulcerative colitis, but is not expressed by regulatory T (Treg) cells. The TH2 transcriptional activator GATA-3 and the Treg–associated transcriptional repressor FOXP3 robustly bind human, but not mouse, GPR15 enhancer sequences, correlating with expression. Our results highlight species differences in GPR15 regulation, and suggest it as a potential therapeutic target for colitis.
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影响因子：
16.6
作者：
通讯作者：
--
影响因子：
14.8
作者：
Fantini, Massimo C.;Dominitzki, Sabine;Becker, Christoph
通讯作者：
Becker, Christoph
影响因子：
2.4
作者：
Kunkel, EJ;Campbell, DJ;Butcher, EC
通讯作者：
Butcher, EC
DOI：
10.1038/nri2476
发表时间：
2009-02
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
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影响因子：
29.4
作者：
Elson, Charles O.;Cong, Yingzi;Kastelein, Robert A.
通讯作者：
Kastelein, Robert A.