Haemoglobin concentration and the risk of death in older adults: differences by race/ethnicity in the NHANES III follow-up.
Haemoglobin concentration and the risk of death in older adults: differences by race/ethnicity in the NHANES III follow-up.
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DOI：
10.1111/j.1365-2141.2009.07659.x
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发表时间：
2009-05
影响因子：
6.5
通讯作者：
Guralnik JM
中科院分区：
文献类型：
--
作者：
Patel KV;Longo DL;Ershler WB;Yu B;Semba RD;Ferrucci L;Guralnik JM
Mildly low hemoglobin concentration is associated with increased mortality in older adults. However, this relationship has not been well characterized in racial/ethnic minorities. Therefore, this study determined the hemoglobin threshold below which risk of death is significantly increased in older non-Hispanic whites, non-Hispanic blacks, and Mexican Americans. Data on 4,089 participants of the 1988-1994 US National Health and Nutrition Examination Survey who were ≥65 years of age were analyzed with mortality follow-up through December 31, 2000. Mean hemoglobin in non-Hispanic whites (n=2,686) and Mexican Americans (n=663) was 140 g/L, while in non-Hispanic blacks (n=740) the mean was 10 g/L lower. A total of 1,944 (47.5%) participants died. Among non-Hispanic whites and Mexican Americans, age- and sex-adjusted models showed that the hemoglobin thresholds below which mortality risk was significantly increased were 4 g/L and 2 g/L, respectively, above the World Health Organization (WHO) cutoffs for anaemia. In contrast, the threshold for non-Hispanic blacks was 7 g/L below the WHO criteria. Similar threshold effects were observed when analyzing hemoglobin in categories and adjusting for multiple confounders. In conclusion, the hemoglobin threshold below which mortality rises significantly is a full g/dL lower in non-Hispanic blacks than in non-Hispanic whites and Mexican Americans.
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DOI：
10.1093/gerona/61.5.474
发表时间：
2006-05-01
影响因子：
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作者：
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DOI：
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