Effects of rTMS Treatment on Cognitive Impairment and Resting-State Brain Activity in Stroke Patients: A Randomized Clinical Trial.
Effects of rTMS Treatment on Cognitive Impairment and Resting-State Brain Activity in Stroke Patients: A Randomized Clinical Trial.
复制标题
rTMS 治疗对中风患者认知障碍和静息态大脑活动的影响：一项随机临床试验
DOI：
10.3389/fncir.2020.563777
复制
发表时间：
2020
影响因子：
3.5
通讯作者：
Hu X
中科院分区：
文献类型：
--
作者：
Yin M;Liu Y;Zhang L;Zheng H;Peng L;Ai Y;Luo J;Hu X
重复经颅磁刺激（rTMS）已被用于脑卒中患者的运动功能康复，但其对脑卒中后认知功能障碍（PSCI）的影响仍存在争议。确定rTMS干预对PSCI患者的影响及其与行为改善的潜在神经相关性。我们招募了34名PSCI患者，在左侧背外侧前额叶皮层（DLPFC）进行20次10 Hz rTMS或无刺激对照治疗。采用蒙特利尔认知评定量表、维多利亚Stroop测验、Rivermead行为记忆测验评价认知功能，采用改良Barthel指数评价日常生活活动能力（ADL）。14名患者接受了功能性MRI扫描，这是一种有用的非侵入性技术，用于确定结构分离和功能专门化的脑区如何相互连接，这是通过血氧水平依赖性信号反映的。低频波动幅度（ALFF）和功能连接（FC）作为分析方法，用于测量静息态脑活动和功能连接。相对于接受无刺激对照治疗的患者，rTMS改善了PSCI患者的认知功能和ADL。认知功能的改善与左侧内侧前额叶皮质的ALFF增加、右侧内侧前额叶皮质和右侧腹侧前扣带回皮质的FC增加相关。DLPFC的10 Hz rTMS可以改善PSCI患者的认知功能和生活质量，这与额叶皮质活动的改变有关。中国临床试验注册中心，ChiCTR-IPR-17011908，www.example.com。
Repetitive transcranial magnetic stimulation (rTMS) has been employed for motor function rehabilitation for stroke patients, but its effects on post-stroke cognitive impairment (PSCI) remains controversial. To identify the effects of rTMS intervention on PSCI patients and its potential neural correlates to behavioral improvements. We recruited 34 PSCI patients for 20 sessions of 10 Hz rTMS or no-stim control treatments over the left dorsal lateral prefrontal cortex (DLPFC). Cognitive function was evaluated with the Montreal Cognitive Assessment Scale, Victoria Stroop Test, Rivermead Behavior Memory Test, and Activities of Daily Living (ADL) assessed with the Modified Barthel Index. 14 patients received functional MRI scan, a useful non-invasive technique of determining how structurally segregated and functionally specialized brain areas were interconnected, which was reflected by blood oxygenation level–dependent signals. The amplitude of low-frequency fluctuation (ALFF) and functional connectivity (FC) were applied as the analytical approaches, which were used to measure the resting-state brain activity and functional connection. rTMS improved cognitive functions and ADLs for PSCI patients relative to patients who received no-stim control treatment. The cognitive improvements correlated to increased ALFF of the left medial prefrontal cortex, and increased FC of right medial prefrontal cortex and right ventral anterior cingulate cortex. 10 Hz rTMS at DLPFC could improve cognitive function and quality of life for PSCI patients, which is associated with an altered frontal cortical activity. Chinese Clinical Trial Registry, ChiCTR-IPR-17011908, http://www.chictr.org.cn/index.aspx.
登录
查看更多内容
DOI：
10.1016/j.clinph.2009.08.016
发表时间：
2009-12
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Rossi S;Hallett M;Rossini PM;Pascual-Leone A;Safety of TMS Consensus Group
通讯作者：
Safety of TMS Consensus Group
DOI：
10.12659/msm.892337
发表时间：
2015-03-14
期刊：
Medical science monitor : international medical journal of experimental and clinical research
影响因子：
--
作者：
Lu H;Zhang T;Wen M;Sun L
通讯作者：
Sun L
影响因子：
3
作者：
McKinney, M;Blake, H;Gladman, JFR
通讯作者：
Gladman, JFR
影响因子：
4.8
作者：
Hamilton, J. Paul;Glover, Gary H.;Hsu, Jung-Jiin;Johnson, Rebecca F.;Gotlib, Ian H.
通讯作者：
Gotlib, Ian H.
DOI：
10.1097/phm.0b013e3181d8a5b1
发表时间：
2010-05-01
影响因子：
3
作者：
Kim, Bo Ryun;Kim, Dae-Yul;Kwon, Jae Sung
通讯作者：
Kwon, Jae Sung