I SPI1 something needed for B cells.

I SPI1 something needed for B cells.
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我发现了B细胞所需的某种物质。

DOI:
10.1084/jem.20210572
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发表时间:
2021-07-05
期刊:
The Journal of experimental medicine
影响因子:
--
通讯作者:
Sankaran VG
Sankaran VG
中科院分区:
其他
文献类型:
--
作者:
Wahlster L;Sankaran VG

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在本期中,Le Coz 等人。优雅地描述了一种由 SPI1 突变引起的新型免疫缺陷综合征,影响血统规范,强调了主转录因子作为细胞命运决定因素的重要作用。在本期中,Le Coz 等人。 (2021. J. Exp. Med. https://doi.org/10.1084/jem.20201750) 描述了一种由 SPI1 突变引起的新型免疫缺陷综合征。通过一系列深入研究,作者深入了解了 SPI1 如何影响血统规范,强调了主转录因子作为细胞命运决定因素的重要作用。
In this issue, Le Coz et al. elegantly describe a novel immunodeficiency syndrome caused by mutations in SPI1, affecting blood lineage specification, highlighting the important role of master transcription factors as cellular fate determinants. In this issue, Le Coz et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20201750) describe a novel immunodeficiency syndrome caused by mutations in SPI1. Through a series of in-depth studies, the authors provide insights into how SPI1 affects blood lineage specification, highlighting the important role of master transcription factors as cellular fate determinants.
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