Physiological and metabolic differences between visceral and subcutaneous adipose tissues in Nile tilapia (Oreochromis niloticus).
Physiological and metabolic differences between visceral and subcutaneous adipose tissues in Nile tilapia (Oreochromis niloticus).
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尼罗罗非鱼（Oreochromis niloticus）内脏和皮下脂肪组织的生理和代谢差异。
DOI：
10.1152/ajpregu.00071.2017
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发表时间：
2017-08
期刊：
影响因子：
--
通讯作者：
Du Zhen-Yu
中科院分区：
文献类型：
--
作者：
Wang Ya-Wen;Zhang Ji-Lei;Jiao Jian-Gang;Du Xiao-Xia;Limbu Samwel Mchele;Qiao Fang;Zhang Mei-Ling;Li Dong-Liang;Du Zhen-Yu
内脏脂肪组织（VAT）和皮下脂肪组织（SCAT）具有不同的结构和代谢功能，并在哺乳动物内分泌系统的调节中起不同的作用。但是，关于形态和生理学知之甚少
Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SCAT) have different structures and metabolic functions and play different roles in the regulation of the mammal endocrine system. However, little is known about morphology and physiological and metabolic functions between VAT and SCAT in fish. We compared the morphological, physiological, and biochemical characteristics of VAT and SCAT in Nile tilapia and measured their functions in energy intake flux, lipolytic ability, and gene expression patterns. SCAT contained more large adipocytes and nonadipocytes than VAT in Nile tilapia. VAT had higher lipid content and was the primary site for lipid deposition. Conversely, SCAT had higher hormone-induced lipolytic activity. Furthermore, SCAT had a higher percentage of monounsaturated and lower polyunsaturated fatty acids than VAT. SCAT had higher mitochondrial DNA, gene expression for fatty acid β-oxidation, adipogenesis, and brown adipose tissue characteristics, but it also had a lower gene expression for inflammation and adipocyte differentiation than VAT. SCAT and VAT have different morphological structures, as well as physiological and metabolic functions in fish. VAT is the preferable lipid deposition tissue, whereas SCAT exhibits higher lipid catabolic activity than VAT. The physiological functions of SCAT in fish are commonly overlooked. The present study indicates that SCAT has specific metabolic characteristics that differ from VAT. The differences between VAT and SCAT should be considered in future metabolism studies using fish as models, either in biomedical or aquaculture studies.
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