Biomaterials in Tendon and Skeletal Muscle Tissue Engineering: Current Trends and Challenges.
Biomaterials in Tendon and Skeletal Muscle Tissue Engineering: Current Trends and Challenges.
复制标题
DOI：
10.3390/ma11071116
复制
发表时间：
2018-06-29
期刊：
影响因子：
--
通讯作者：
Legallais C
中科院分区：
文献类型：
--
作者：
Beldjilali-Labro M;Garcia Garcia A;Farhat F;Bedoui F;Grosset JF;Dufresne M;Legallais C
组织工程是一种很有前途的方法来修复自然愈合失败的肌腱和肌肉。在细胞接种和在专用支架中培养后获得的生物杂交构建体确实被认为是用于模拟天然组织的相关工具，从而导致更好的体内整合。它们还可以用于进行先进的体外研究，以模拟细胞分化或再生过程。在这篇综述中，我们报告并分析了文献中提出的不同解决方案，用于肌腱，肌肉和肌腱连接处的重建。它们典型地依赖于组织工程的三大支柱，即，细胞、生物材料和环境（化学和物理刺激）。我们已经选择提出基于对感兴趣组织的天然组织结构/功能/特性的理解的仿生或生物启发策略。对于每种组织，我们根据材料形状或制造的复杂程度的增加对相关出版物进行了分类。我们介绍了它们的生物和机械性能，在体外和体内观察时可用。虽然对于重建这些肌肉骨骼组织的金标准技术没有共识，但读者可以找到不同的方法来在该领域取得进展，并了解材料选择的最新历史，从胶原蛋白到聚合物基质。
Tissue engineering is a promising approach to repair tendon and muscle when natural healing fails. Biohybrid constructs obtained after cells’ seeding and culture in dedicated scaffolds have indeed been considered as relevant tools for mimicking native tissue, leading to a better integration in vivo. They can also be employed to perform advanced in vitro studies to model the cell differentiation or regeneration processes. In this review, we report and analyze the different solutions proposed in literature, for the reconstruction of tendon, muscle, and the myotendinous junction. They classically rely on the three pillars of tissue engineering, i.e., cells, biomaterials and environment (both chemical and physical stimuli). We have chosen to present biomimetic or bioinspired strategies based on understanding of the native tissue structure/functions/properties of the tissue of interest. For each tissue, we sorted the relevant publications according to an increasing degree of complexity in the materials’ shape or manufacture. We present their biological and mechanical performances, observed in vitro and in vivo when available. Although there is no consensus for a gold standard technique to reconstruct these musculo-skeletal tissues, the reader can find different ways to progress in the field and to understand the recent history in the choice of materials, from collagen to polymer-based matrices.
登录
查看更多内容
影响因子：
82.9
作者：
Bi, Yanming;Ehirchiou, Driss;Young, Marian F.
通讯作者：
Young, Marian F.
DOI：
10.1111/j.1365-2613.2007.00552.x
发表时间：
2007-08-07
影响因子：
3
作者：
Birch, Helen L.
通讯作者：
Birch, Helen L.
DOI：
10.1007/s10856-015-5656-3
发表时间：
2016-03
期刊：
Journal of materials science. Materials in medicine
影响因子：
--
作者：
Aibibu D;Hild M;Wöltje M;Cherif C
通讯作者：
Cherif C
影响因子：
6.6
作者：
Adam, RM;Roth, JA;Freeman, MR
通讯作者：
Freeman, MR
DOI：
10.1152/ajpendo.00450.2013
发表时间：
2014-04-01
影响因子：
5.1
作者：
Bustamante, Mario;Fernandez-Verdejo, Rodrigo;Buvinic, Sonja
通讯作者：
Buvinic, Sonja