Striatal Hypersensitivity During Stress in Remitted Individuals with Recurrent Depression.
Striatal Hypersensitivity During Stress in Remitted Individuals with Recurrent Depression.
复制标题
DOI：
10.1016/j.biopsych.2014.09.019
复制
发表时间：
2015-07-01
影响因子：
10.6
通讯作者：
Pizzagalli DA
中科院分区：
文献类型：
--
作者：
Admon R;Holsen LM;Aizley H;Remington A;Whitfield-Gabrieli S;Goldstein JM;Pizzagalli DA
Increased sensitivity to stress and dysfunctional reward processing are two primary characteristics of Major Depressive Disorder (MDD) that may persist following remission. Preclinical work has established the pivotal role of the striatum in mediating both stress and reward responses. Human neuroimaging studies have corroborated these preclinical findings and highlighted striatal dysfunction in MDD in response to reward, but have yet to investigate striatal function during stress, in particular in individuals with recurrent depression. Thirty three remitted individuals with a history of recurrent MDD (rMDD) and 35 matched healthy controls underwent a validated mild psychological stress task involving viewing of negative stimuli during fMRI. Cortisol and anxiety levels were assessed throughout scanning. Stress-related activation was investigated in three striatal regions: caudate, nucleus accumbens (Nacc), and putamen. Psychophysiological interaction (PPI) analyses probed connectivity of those regions with central structures of the neural stress circuitry, the amygdala and hippocampus. The task increased cortisol and anxiety levels, although to a greater extent in rMDD than healthy controls. In response to the negative stimuli, rMDD individuals, but not controls, also exhibited significantly potentiated caudate, Nacc, and putamen activations, as well as increased caudate-amygdala and caudate-hippocampus connectivity. Findings highlight striatal hyper-sensitivity in response to a mild psychological stress in rMDD, as manifested by hyper-activation and hyper-connectivity with the amygdala and hippocampus. Striatal hyper-sensitivity during stress might thus constitute a trait mark of depression, providing a potential neural substrate for the interaction between stress and reward dysfunction in MDD.
登录
查看更多内容
DOI：
10.1523/jneurosci.3021-09.2010
发表时间：
2010-01-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Goldstein JM;Jerram M;Abbs B;Whitfield-Gabrieli S;Makris N
通讯作者：
Makris N
影响因子：
2.9
作者：
Berghorst LH;Bogdan R;Frank MJ;Pizzagalli DA
通讯作者：
Pizzagalli DA
影响因子：
5.3
作者：
Goldstein, JM;Jerram, M;Makris, N
通讯作者：
Makris, N
影响因子：
4.6
作者：
BERENBAUM, H;CONNELLY, J
通讯作者：
CONNELLY, J
DOI：
10.1176/appi.ajp.2008.07081336
发表时间：
2009-01
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Forbes EE;Hariri AR;Martin SL;Silk JS;Moyles DL;Fisher PM;Brown SM;Ryan ND;Birmaher B;Axelson DA;Dahl RE
通讯作者：
Dahl RE