Association between urinary cadmium levels and prediabetes in the NHANES 2005-2010 population.
Association between urinary cadmium levels and prediabetes in the NHANES 2005-2010 population.
复制标题
DOI：
10.1016/j.ijheh.2014.06.005
复制
发表时间：
2014-11
影响因子：
6
通讯作者：
El Muayed, Malek
中科院分区：
文献类型：
--
作者：
Wallia, Amisha;Allen, Norrina Bai;Badon, Sylvia;El Muayed, Malek
有证据表明，接触镉与血糖异常之间存在关联。为了研究这一问题，我们在横断面国民健康与营养调查(NHANES)中调查了尿镉与糖尿病前期的关系。2005年至2010年≥40岁的NHANES参与者被包括在分析中。患有肾病、明显糖尿病或丢失所需数据的参与者被排除在外。为了评价镉与糖尿病前期的非线性关系，采用非参数Logistic回归方法对尿镉/肌酐比值进行了B样条展开式分析。这项分析揭示了较高的镉水平和糖尿病前期之间复杂的非线性关联。这种关系一直存在，尽管吸烟者(从不吸烟者、中度吸烟者和重度吸烟者)的吸烟率不同。在传统的Logistic回归分析中，这种关系不那么明显，与总人口和中等吸烟者中最低的五分之一的尿镉相比，糖尿病前期患者尿镉的最高五分位数的OR显著增加。在年龄分层分析中，只在60-69岁和≥70岁的年龄组中发现了显著的线性关联。我们得出结论，尿镉水平、年龄、吸烟习惯和患糖尿病前期的几率之间存在显著的非线性复杂关系。
Evidence suggests an association between exposure to cadmium and dysglycemia. To investigate this matter, we examined the relationship between urinary cadmium and prediabetes in the cross sectional National Health and Nutrition Examination Survey (NHANES). NHANES participants for the years 2005 through 2010 aged ≥40 years were included in the analysis. Participants with nephropathy, overt diabetes, or missing required data were excluded. To assess the non-linear relationship between cadmium and Prediabetes, non-parametric logistic regression with B spline expansion of urinary cadmium/creatinine ratio was performed. This analysis revealed a complex non-linear association between higher cadmium levels and prediabetes. This relationship persisted, though with varying magnitudes across smoking groups (never smokers, moderate smokers, heavy smokers). In a conventional logistic regression analysis, this relationship was less evident with significantly increased OR for prediabetes was found in the highest quintile of urine cadmium compared to the lowest quintile in the overall population and in moderate smokers. In an age stratified analysis, a significant linear association was found only in the age groups 60–69 and ≥70. We conclude that there is a significant non-linear, complex relationship between urinary Cd levels, age, smoking habits and odds of prediabetes.
登录
查看更多内容
DOI：
10.1016/j.ijheh.2011.06.007
发表时间：
2011-12-01
影响因子：
6
作者：
Schulz, Christine;Wilhelm, Michael;Kolossa-Gehring, Marike
通讯作者：
Kolossa-Gehring, Marike
影响因子：
5.1
作者：
Afridi, Hassan Imran;Kazi, Tasneem Gul;Sarfraz, Raja Adil
通讯作者：
Sarfraz, Raja Adil
影响因子：
4.5
作者：
Dakeshita, Satoru;Kawai, Tomoko;Arisawa, Kokichi
通讯作者：
Arisawa, Kokichi
影响因子：
2.8
作者：
Orlowski, C;Piotrowski, JK;Gross, A
通讯作者：
Gross, A
影响因子：
3.5
作者：
Ruiz, Patricia;Mumtaz, Moiz;Fowler, Bruce A.
通讯作者：
Fowler, Bruce A.