Sleep-disordered breathing and daytime napping are associated with maternal hyperglycemia.
Sleep-disordered breathing and daytime napping are associated with maternal hyperglycemia.
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DOI：
10.1007/s11325-013-0809-4
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发表时间：
2013-09
影响因子：
2.5
通讯作者：
Pien, Grace W.
中科院分区：
文献类型：
--
作者：
Balserak, Bilgay Izci;Jackson, Nicholas;Ratcliffe, Sarah A.;Pack, Allan I.;Pien, Grace W.
妊娠期睡眠障碍可能损害血糖机制。本研究的目的是在控制已知的妊娠期糖尿病危险因素后，检查睡眠呼吸障碍、睡眠和午睡时间与孕妇1小时葡萄糖激发试验（GCT）水平的相关性。这是一项对104名孕妇进行的病例对照研究。所有女性均接受了完整的多导睡眠图和葡萄糖激发试验（GCT），并完成了多变量呼吸暂停预测和匹兹堡睡眠质量指数。主要结局是通过GCT测量的母体高血糖。进行了双变量和多变量logistic回归分析。超过13%的受试者报告在妊娠早期有习惯性打鼾。正常血糖（GCT<135）的女性中仅有9.3%为习惯性打鼾，而高血糖（GCT≥135）的女性中有45.5%为习惯性打鼾（p<0.001）。睡眠呼吸障碍症状（大声打鼾、打鼾/喘息和呼吸暂停）（比值比（OR）2.85; 95%置信区间（CI）1.50-5.41; p=0.001）和总午睡时间（OR 1.48; 95% CI 0.96-2.28; p=0.08）与高血压相关。调整混杂因素后，睡眠呼吸障碍症状（OR 3.37; 95%CI，1.44-8.32; p=0.005）和午睡持续时间（OR 1.64; 95%CI，1.00-2.681.02; p=0.05）继续与高血压相关。然而，主要暴露指标，妊娠早期呼吸暂停/呼吸不足指数与高血压血症无显著相关性（OR 1.03; 95% CI 0.83-1.28; p=0.77）。睡眠呼吸障碍症状和午睡时间与高血压相关。睡眠时间与高血压无关。需要研究睡眠呼吸障碍和/或白天午睡的女性是否有患妊娠糖尿病的风险。
Sleep disturbances in pregnancy may impair glucose mechanism. This study aimed to examine associations of sleep-disordered breathing, sleep and nap-duration with one-hour glucose challenge test (GCT) levels in pregnant women after controlling for known risk factors for gestational diabetes. This is a case-control study of 104 pregnant women. All women underwent full polysomnography and a glucose challenge test (GCT), and completed the Multivariable Apnoea Prediction and Pittsburgh Sleep Quality Indexes. The primary outcome was maternal hyperglycaemia measured by GCT. Bivariate and multivariable logistic regression analyses were performed. Over 13% subjects reported habitual snoring in the first trimester. Only 9.3% women with normoglycaemia (GCT<135) were habitual snorers, whereas 45.5% women with hyperglycaemia-(GCT≥135) had habitual snoring (p<0.001). Sleep-disordered breathing symptoms (loud snoring, snorting/gasping and apnoeas), (odds ratio (OR) 2.85; 95% confidence interval (CI) 1.50–5.41; p=0.001) and total nap-duration (OR 1.48; 95% CI 0.96–2.28; p=0.08) were associated with hyperglycaemia. After adjusting for confounders, sleep-disordered breathing symptoms (OR 3.37; 95% CI, 1.44–8.32; p=0.005) and nap-duration (OR 1.64; 95% CI, 1.00–2.681.02; p=0.05) continued to be associated with hyperglycaemia. However, the primary exposure measure, the apnea/hypopnea index in the first-trimester was not significantly associated with hyperglycaemia (OR 1.03; 95% CI 0.83–1.28; p=0.77). Sleep-disordered breathing symptoms and nap duration are associated with hyperglycaemia. Sleep-duration was not associated with hyperglycaemia. Research is needed concerning whether women with sleep-disordered breathing and/or daytime napping are at risk for gestational diabetes.
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影响因子：
16.2
作者：
Foster GD;Sanders MH;Millman R;Zammit G;Borradaile KE;Newman AB;Wadden TA;Kelley D;Wing RR;Sunyer FX;Darcey V;Kuna ST;Sleep AHEAD Research Group
通讯作者：
Sleep AHEAD Research Group
影响因子：
3.3
作者：
Izci-Balserak, Bilgay;Pien, Grace W.
通讯作者：
Pien, Grace W.
影响因子：
16.2
作者：
Ayas, NT;White, DP;Hu, FB
通讯作者：
Hu, FB
影响因子：
9.8
作者：
Herring, Sharon J.;Oken, Emily;Rifas-Shiman, Sheryl L.;Rich-Edwards, Janet W.;Stuebe, Alison M.;Kleinman, Ken P.;Gillman, Matthew W.
通讯作者：
Gillman, Matthew W.
DOI：
10.1164/rccm.200909-1423oc
发表时间：
2010-03-01
影响因子：
24.7
作者：
Aronsohn, Renee S.;Whitmore, Harry;Tasali, Esra
通讯作者：
Tasali, Esra