Serum antigliadin antibodies in cerebellar ataxias: a systematic review and meta-analysis.
Serum antigliadin antibodies in cerebellar ataxias: a systematic review and meta-analysis.
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DOI：
10.1136/jnnp-2018-318215
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发表时间：
2018-11
期刊：
影响因子：
--
通讯作者：
Kuo SH
中科院分区：
文献类型：
--
作者：
Lin CY;Wang MJ;Tse W;Pinotti R;Alaedini A;Green PHR;Kuo SH
谷蛋白敏感性是指对谷蛋白的突出免疫反应，通常与血清抗麦胶蛋白抗体（AGA）水平升高有关。AGA与小脑共济失调之间的关系一直不一致的报道。我们进行了系统的文献检索和荟萃分析，使用固定效应模型研究特发性小脑性共济失调（IDCA）病例与对照组或遗传性共济失调（HA）的AGA血清阳性加权汇总OR。纳入11项研究，共847例IDCA病例，1654例对照和445例HA病例。IDCA患者AGA血清阳性的几率比对照组高4倍（OR 4.28, 95% CI 3.10 ~ 5.90），比HA患者高2倍（OR 2.23, 95% CI 1.45 ~ 3.44）。排除权重最大的研究（占总权重的69%）的敏感性分析仍然显示出类似的关联（IDCA vs对照，OR 3.18, 95% CI 1.79至5.67,IDCA vs HA, OR 1.72, 95% CI 1.03至2.86）。亚组分析显示，与对照组相比，东亚和西方国家的IDCA病例AGA血清阳性的几率约为3至4倍（分别为OR 3.41, 95% CI 1.67至6.97和OR 4.53, 95% CI 3.16至6.49），表明缺乏种族异质性。HA病例中AGA血清阳性的几率没有显著高于对照组（OR 1.41, 95% CI 0.82 ~ 2.44）。我们的研究表明AGA和IDCA之间存在关联，在不同的地理区域。
Gluten sensitivity refers to prominent immunological responses to gluten, usually in conjunction with elevated levels of serum antigliadin antibody (AGA). The association between AGA and cerebellar ataxias has been inconsistently reported. We performed a systematic literature search and a meta-analysis to study the weighted pooled OR of idiopathic cerebellar ataxia (IDCA) cases to controls or to hereditary ataxia (HA) for AGA seropositivity using fixed effect model. Eleven studies were included, with a total of 847 IDCA cases, 1654 controls and 445 HA cases. IDCA cases had fourfold higher odds than controls (OR 4.28, 95% CI 3.10 to 5.90) and twofold higher odds than HA cases (OR 2.23, 95% CI 1.45 to 3.44) of having AGA seropositivity. Sensitivity analysis excluding the most weighted study, which accounted for 69% of the total weight, still showed similar associations (IDCA vs controls, OR 3.18, 95% CI 1.79 to 5.67 and IDCA vs HA, OR 1.72, 95% CI 1.03 to 2.86, respectively). The subgroup analysis showed that, when compared with controls, IDCA cases of both East Asian and Western countries had approximately threefold to fourfold higher odds to have AGA seropositivity (OR 3.41, 95% CI 1.67 to 6.97 and OR 4.53, 95% CI 3.16 to 6.49, respectively), suggesting the lack of ethnic heterogeneity. The odds of AGA seropositivity for HA cases was not significantly higher than controls (OR 1.41, 95% CI 0.82 to 2.44). Our study indicates the association between AGA and IDCA, across different geographic regions.
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影响因子：
5.9
作者：
Catassi C;Bai JC;Bonaz B;Bouma G;Calabrò A;Carroccio A;Castillejo G;Ciacci C;Cristofori F;Dolinsek J;Francavilla R;Elli L;Green P;Holtmeier W;Koehler P;Koletzko S;Meinhold C;Sanders D;Schumann M;Schuppan D;Ullrich R;Vécsei A;Volta U;Zevallos V;Sapone A;Fasano A
通讯作者：
Fasano A
影响因子：
168.9
作者：
Hadjivassiliou, M;Gibson, A;MilfordWard, A
通讯作者：
MilfordWard, A
DOI：
10.1007/s12311-015-0664-x
发表时间：
2016-04
期刊：
Cerebellum (London, England)
影响因子：
--
作者：
Mitoma H;Adhikari K;Aeschlimann D;Chattopadhyay P;Hadjivassiliou M;Hampe CS;Honnorat J;Joubert B;Kakei S;Lee J;Manto M;Matsunaga A;Mizusawa H;Nanri K;Shanmugarajah P;Yoneda M;Yuki N
通讯作者：
Yuki N
影响因子：
9.9
作者：
Hadjivassiliou, Marios;Aeschlimann, Pascale;Aeschlimann, Daniel P.
通讯作者：
Aeschlimann, Daniel P.
中国大陆患者散发性和遗传性小脑性共济失调的麸质共济失调。
影响因子：
2.7
作者：
Guan, Wen-Juan;Liu, Xin-Jian;Wang, Jun-Ling
通讯作者：
Wang, Jun-Ling