Sex differences in extinction recall in posttraumatic stress disorder: a pilot fMRI study.
Sex differences in extinction recall in posttraumatic stress disorder: a pilot fMRI study.
复制标题
DOI：
10.1016/j.nlm.2014.02.003
复制
发表时间：
2014-09
影响因子：
2.7
通讯作者：
Neria Y
中科院分区：
文献类型：
--
作者：
Shvil E;Sullivan GM;Schafer S;Markowitz JC;Campeas M;Wager TD;Milad MR;Neria Y
Recent research has found that individuals with posttraumatic stress disorder (PTSD) exhibit an impaired memory of fear extinction compounded by deficient functional activation of key nodes of the fear network including the amygdala, hippocampus, ventromedial prefrontal cortex (vmPFC) and dorsal anterior cingulate cortex (dACC). Research has shown these regions are sexually dimorphic and activate differentially in healthy men and women during fear learning tasks. To explore biological markers of sex differences following exposure to psychological trauma, we used a fear learning and extinction paradigm together with functional magnetic resonance imaging (fMRI) and skin conductance response (SCR) to assess 31 individuals with PTSD (18 women; 13 men) and 25 matched trauma-exposed healthy control subjects (13 women; 12 men). Whereas no sex differences appeared within the trauma-exposed healthy control group, both psychophysiological and neural activation patterns within the PTSD group indicated deficient recall of extinction memory among men and not among women. Men with PTSD exhibited increased activation in the left rostral dACC during extinction recall compared with women with PTSD. These findings highlight the importance of tracking sex differences in fear extinction when characterizing the underlying neurobiological mechanisms of PTSD psychopathology.
登录
查看更多内容
DOI：
10.1523/jneurosci.3021-09.2010
发表时间：
2010-01-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Goldstein JM;Jerram M;Abbs B;Whitfield-Gabrieli S;Makris N
通讯作者：
Makris N
影响因子：
19.9
作者：
Etkin, Amit;Egner, Tobias;Kalisch, Raffael
通讯作者：
Kalisch, Raffael
影响因子：
--
作者：
KESSLER, RC;SONNEGA, A;NELSON, CB
通讯作者：
NELSON, CB
影响因子：
3.3
作者：
Milad, M. R.;Zeidan, M. A.;Goldstein, J. M.
通讯作者：
Goldstein, J. M.
影响因子：
4.6
作者：
Breslau, Naomi;Anthony, James C.
通讯作者：
Anthony, James C.