Antidepressant medications reduce subcortical-cortical resting-state functional connectivity in healthy volunteers.
Antidepressant medications reduce subcortical-cortical resting-state functional connectivity in healthy volunteers.
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DOI：
10.1016/j.neuroimage.2011.05.051
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发表时间：
2011-08-15
期刊：
影响因子：
5.7
通讯作者：
Mishor, Zevic
中科院分区：
文献类型：
--
作者：
McCabe, Ciara;Mishor, Zevic
研究表明，重度抑郁症患者静息状态功能连接异常，特别是在扣带背前部、丘脑、杏仁核、苍白纹状体和亚属扣带等区域。然而，抗抑郁药物对人脑功能的影响尚不清楚，这些药物对静息状态功能连通性的影响尚不清楚。40名年龄和性别匹配且无精神病史的志愿者在双盲设计中接受西酞普兰（选择性血清素能再摄取抑制剂）、瑞波西汀（选择性去甲肾上腺素能再摄取抑制剂）或安慰剂治疗7天。利用静息状态功能磁共振成像和基于种子的连通性分析，我们选择右侧伏隔核、右侧杏仁核、亚属扣带和前额叶背内侧皮层作为种子区。使用自我报告量表测量服药前后的情绪和主观体验。尽管三组之间的情绪没有差异，但我们发现西酞普兰组的杏仁核和腹侧内侧前额叶皮层之间的连通性降低了，瑞波西汀组的杏仁核和眶额叶皮层之间的连通性降低了。我们还发现瑞波西汀组纹状体-眶额叶皮质连通性降低。这些数据表明，抗抑郁药物可以减少静息状态的功能连接，而不受情绪变化的影响，这些功能连接位于大脑中调节奖励和情绪处理的区域。我们的结论是，静息状态fMRI基于假设驱动的种子分析支持这样的命题，即抗抑郁药物可能通过使抑郁症患者中升高的静息状态功能连接正常化而起作用。►我们研究了两种抗抑郁药（西酞普兰和瑞波西汀）治疗7天对健康志愿者静息状态功能连通性的影响。西酞普兰和瑞波西汀都能降低杏仁核种子区和前额皮质之间的功能连接。抗抑郁作用可能涉及静息状态网络关键元素之间的静息状态功能连接的正常化。
Studies have revealed abnormalities in resting-state functional connectivity in those with major depressive disorder specifically in areas such as the dorsal anterior cingulate, thalamus, amygdala, the pallidostriatum and subgenual cingulate. However, the effect of antidepressant medications on human brain function is less clear and the effect of these drugs on resting-state functional connectivity is unknown. Forty volunteers matched for age and gender with no previous psychiatric history received either citalopram (SSRI; selective serotonergic reuptake inhibitor), reboxetine (SNRI; selective noradrenergic reuptake inhibitor) or placebo for 7 days in a double-blind design. Using resting-state functional magnetic resonance imaging and seed based connectivity analysis we selected the right nucleus accumbens, the right amygdala, the subgenual cingulate and the dorsal medial prefrontal cortex as seed regions. Mood and subjective experience were also measured before and after drug administration using self-report scales. Despite no differences in mood across the three groups, we found reduced connectivity between the amygdala and the ventral medial prefrontal cortex in the citalopram group and the amygdala and the orbitofrontal cortex for the reboxetine group. We also found reduced striatal–orbitofrontal cortex connectivity in the reboxetine group. These data suggest that antidepressant medications can decrease resting-state functional connectivity independent of mood change and in areas known to mediate reward and emotional processing in the brain. We conclude that hypothesis-driven seed based analysis of resting-state fMRI supports the proposition that antidepressant medications might work by normalising the elevated resting-state functional connectivity seen in depressed patients. ► We examine the effects of 7 day treatment with two antidepressants (citalopram and reboxetine) on resting-state functional connectivity in healthy volunteers. ► Both citalopram and reboxetine reduce functional connectivity between the amygdala seed region and the prefrontal cortex. ► Antidepressant action may involve normalisation of elevated resting-state functional connectivity between key elements of resting-state networks.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
10.6
作者：
Frodl, Thomas;Bokde, Arun L. W.;Meisenzahl, Eva
通讯作者：
Meisenzahl, Eva
影响因子：
10.6
作者：
Greicius, Michael D.;Flores, Benjamin H.;Schatzberg, Alan F.
通讯作者：
Schatzberg, Alan F.
影响因子：
10.5
作者：
Harmer, Catherine J.;Goodwin, Guy M.;Cowen, Philip J.
通讯作者：
Cowen, Philip J.
影响因子：
--
作者：
DeRubeis, RJ;Hollon, SD;Gallop, R
通讯作者：
Gallop, R