Biomarkers identified with time-lapse imaging: discovery, validation, and practical application.
Biomarkers identified with time-lapse imaging: discovery, validation, and practical application.
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DOI：
10.1016/j.fertnstert.2013.01.143
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发表时间：
2013-03-15
影响因子：
6.7
通讯作者：
Shen S
中科院分区：
文献类型：
--
作者：
Chen AA;Tan L;Suraj V;Reijo Pera R;Shen S
“延时标记物”是由延时成像定义的，与临床结果相关，可能为胚胎学家提供改进胚胎选择的新机会。本文提供了一个概述的非侵入性的生物标志物定义的时间推移成像研究。除了全面回顾每种延时标记物的发现外，它还关注成功整合到临床实践中所需的标准，包括[1]统计学和生物学意义，[2]通过前瞻性临床研究进行验证，以及[3]开发可靠的技术来测量和量化延时标记物。由于人工分析延时图像是劳动密集型的，并且限制了图像数据在临床中的实际使用，因此自动化图像分析软件平台可以大大有助于提高胚胎选择的准确性。最终，基于基础研究基础、通过前瞻性临床研究验证并通过可靠的量化技术实现的时间推移标记物可能会提高IVF成功率，鼓励更广泛地采用单胚胎移植，并降低与多胎妊娠相关的风险。
“Time-lapse markers,” which are defined by time-lapse imaging and correlated with clinical outcomes, may provide embryologists with new opportunities for improving embryo selection. This article provides an overview of noninvasive biomarkers defined by time-lapse imaging studies. In addition to comprehensively reviewing the discovery of each time-lapse marker, it focuses on the criteria necessary for their successful integration into clinical practice, including [1] statistical and biological significance, [2] validation through prospective clinical studies, and [3] development of reliable technology to measure and quantify the time-lapse marker. Because manual analysis of time-lapse images is labor intensive and limits the practical use of the image data in the clinic, automated image analysis software platforms may contribute substantially to improvements in embryo selection accuracy. Ultimately, time-lapse markers that are based on a foundation of basic research, validated through prospective clinical studies, and enabled by a reliable quantification technology may improve IVF success rates, encourage broader adoption of single-embryo transfer, and reduce the risks associated with multiple gestation pregnancies.
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