Bu Shen Huo Xue decoction restores endometrial leukemia-inhibitory factor but not Angiopoietin-2 expression, and improves uterine receptivity in the controlled ovarian stimulation rat model.
Bu Shen Huo Xue decoction restores endometrial leukemia-inhibitory factor but not Angiopoietin-2 expression, and improves uterine receptivity in the controlled ovarian stimulation rat model.
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DOI：
10.3892/etm.2015.2193
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发表时间：
2015-03
影响因子：
2.7
通讯作者：
Jin Z
中科院分区：
文献类型：
--
作者：
Gong X;Lou J;Lu Q;Huang H;Jin Z
白血病抑制因子（LIF）和血管生成素-2（Ang-2）是影响生育的重要因子。在本研究中，它是调查是否补肾活血汤（BSHXD）防止控制性超排卵（COH）治疗引起的子宫内膜LIF和Ang-2表达的变化，以及它是否具有对着床点和活产数的影响。分别于妊娠第3、4、5天取子宫，采用Western blot和定量PCR方法检测LIF和Ang-2蛋白及mRNA的表达。在妊娠D10，观察着床部位的平均数量。记录每组的活产数量。结果表明，BSHXD治疗通过恢复COH大鼠模型中子宫内膜LIF表达和着床能力显着增加活产数。此外，LIF和Ang-2表达之间没有关联。因此，这表明BSHXD可能对女性生殖有用。
Leukemia-inhibitory factor (LIF) and Angiopoietin-2 (Ang-2) are important factors in fertility. In the present study, it was investigated whether Bu Shen Huo Xue Decoction (BSHXD) prevents controlled ovarian hyperstimulation (COH) treatment-induced changes in endometrial LIF and Ang-2 expression and whether it has an effect on the number of implantation sites and live births in rats. Uteri were collected on day (D) 3, 4 and 5 of pregnancy, and LIF and Ang-2 protein and mRNA expression were detected using western blot analysis and quantitative polymerase chain reaction. On pregnancy D10, the average number of implantation sites was observed. The number of live births from each group was recorded. The results indicated that BSHXD treatment markedly increased the number of live births by restoring endometrial LIF expression and the implantation capacity in the COH rat model. In addition, no association was identified between LIF and Ang-2 expression. Therefore, this suggests that BSHXD may be useful for female reproduction.
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