Association between Mastication, the Hippocampus, and the HPA Axis: A Comprehensive Review.
Association between Mastication, the Hippocampus, and the HPA Axis: A Comprehensive Review.
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DOI：
10.3390/ijms18081687
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发表时间：
2017-08-03
影响因子：
5.6
通讯作者：
Kubo KY
中科院分区：
文献类型：
--
作者：
Azuma K;Zhou Q;Niwa M;Kubo KY
咀嚼主要是在牙齿的帮助下进行食物的摄取和营养的消化。咀嚼对于保持和促进整体健康也很重要，包括依赖于大脑的认知。动物和人类研究表明，咀嚼通过下丘脑-垂体-肾上腺（HPA）轴的终产物糖皮质激素（GC）影响海马功能。流行病学研究表明，老年人的咀嚼功能障碍，如牙齿脱落和牙周炎，作为慢性应激的来源，激活HPA轴，导致循环GC增加，并最终诱发各种生理和心理疾病，如认知障碍，心血管疾病和骨质疏松症。最近的研究表明，咀嚼刺激或咀嚼在应激条件下抑制HPA轴的过度活跃，通过GC和GC受体在海马，并改善慢性应激诱导的海马依赖性认知缺陷。在这里，我们提供了一个全面的概述，目前的研究有关咀嚼，海马和HPA轴活动之间的关联。我们还讨论了咀嚼，海马功能和HPA轴活动之间的相互作用的几个潜在的分子机制。
Mastication is mainly involved in food intake and nutrient digestion with the aid of teeth. Mastication is also important for preserving and promoting general health, including hippocampus-dependent cognition. Both animal and human studies indicate that mastication influences hippocampal functions through the end product of the hypothalamic-pituitary-adrenal (HPA) axis, glucocorticoid (GC). Epidemiologic studies suggest that masticatory dysfunction in aged individuals, such as that resulting from tooth loss and periodontitis, acting as a source of chronic stress, activates the HPA axis, leading to increases in circulating GCs and eventually inducing various physical and psychological diseases, such as cognitive impairment, cardiovascular disorders, and osteoporosis. Recent studies demonstrated that masticatory stimulation or chewing during stressful conditions suppresses the hyperactivity of the HPA axis via GCs and GC receptors within the hippocampus, and ameliorates chronic stress-induced hippocampus-dependent cognitive deficits. Here, we provide a comprehensive overview of current research regarding the association between mastication, the hippocampus, and HPA axis activity. We also discuss several potential molecular mechanisms involved in the interactions between mastication, hippocampal function, and HPA axis activity.
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影响因子：
3.6
作者：
Azuma K;Ogura M;Kondo H;Suzuki A;Hayashi S;Iinuma M;Onozuka M;Kubo KY
通讯作者：
Kubo KY
DOI：
10.1152/ajpgi.00095.2013
发表时间：
2014-02-01
影响因子：
4.5
作者：
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通讯作者：
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影响因子：
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作者：
GILAD, GM
通讯作者：
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1.9
作者：
Gómez, FM;Giralt, MT;García-Vallejo, P
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García-Vallejo, P
影响因子：
3.9
作者：
Aguilera, Greti
通讯作者：
Aguilera, Greti