Limited cross-variant immune response from SARS-CoV-2 Omicron BA.2 in naïve but not previously infected outpatients.
Limited cross-variant immune response from SARS-CoV-2 Omicron BA.2 in naïve but not previously infected outpatients.
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DOI：
10.1016/j.isci.2022.105369
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发表时间：
2022-11-18
期刊：
影响因子：
5.8
通讯作者：
Hennighausen, Lothar
中科院分区：
文献类型：
--
作者：
Lee, Hye Kyung;Knabl, Ludwig;Walter, Mary;Furth, Priscilla A.;Hennighausen, Lothar
OMICRON目前是SARS-CoV-2的主要变种，已经出现了几个亚型。以前的SARS-CoV-2暴露对SARS-CoV-2 Omicron亚型BA.2与BA.1引发的交叉变异免疫反应的影响仍然存在疑问。在这里，我们表明，与BA1感染相比，没有新冠肺炎既往病史的BA2感染诱导对所有关注变种(VOC)的免疫反应降低。以前幼稚的BA.1和BA.2患者的血清中没有ACE2结合，表明缺乏有意义的中和作用。相比之下，有新冠肺炎病史的BA.1和BA.2患者的抗尖峰抗体水平和中和活性大大增加。外周血免疫细胞转录组分析显示，BA.1和BA.2患者在免疫应答和特异性抗体产生方面有显著差异，特异性免疫基因表达也有显著差异。总之，既往感染状态显著影响BA.2感染后针对VOC的先天和获得性免疫反应。无新冠肺炎病史的Omicron BA.2患者的免疫反应降低有新冠肺炎病史的BA.1和BA.2患者的免疫反应升高。
Omicron is currently the dominant SARS-CoV-2 variant and several sublineages have emerged. Questions remain about the impact of previous SARS-CoV-2 exposure on cross-variant immune responses elicited by the SARS-CoV-2 Omicron sublineage BA.2 compared to BA.1. Here we show that without previous history of COVID-19, BA.2 infection induces a reduced immune response against all variants of concern (VOC) compared to BA.1 infection. The absence of ACE2 binding in sera of previously naïve BA.1 and BA.2 patients indicates a lack of meaningful neutralization. In contrast, anti-spike antibody levels and neutralizing activity greatly increased in the BA.1 and BA.2 patients with a previous history of COVID-19. Transcriptome analyses of peripheral immune cells showed significant differences in immune response and specific antibody generation between BA.1 and BA.2 patients as well as significant differences in the expression of specific immune genes. In summary, prior infection status significantly impacts the innate and adaptive immune response against VOC following BA.2 infection. Reduced immune response in Omicron BA.2 patients without previous history of COVID-19 Elevated immune response in BA.1 and BA.2 patients with a previous history of COVID-19 Distinct antibody creation and immune gene expression between BA.1 and BA.2 patients Immune response; Virology; Transcriptomics.
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影响因子：
48
作者：
Huber W;Carey VJ;Gentleman R;Anders S;Carlson M;Carvalho BS;Bravo HC;Davis S;Gatto L;Girke T;Gottardo R;Hahne F;Hansen KD;Irizarry RA;Lawrence M;Love MI;MacDonald J;Obenchain V;Oleś AK;Pagès H;Reyes A;Shannon P;Smyth GK;Tenenbaum D;Waldron L;Morgan M
通讯作者：
Morgan M
影响因子：
46.9
作者：
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通讯作者：
Chudakov DM
DOI：
10.1093/bioinformatics/btu638
发表时间：
2015-01-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Anders S;Pyl PT;Huber W
通讯作者：
Huber W
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影响因子：
39.3
作者：
He B;Liu S;Wang Y;Xu M;Cai W;Liu J;Bai W;Ye S;Ma Y;Hu H;Meng H;Sun T;Li Y;Luo H;Shi M;Du X;Zhao W;Chen S;Yang J;Zhu H;Jie Y;Yang Y;Guo D;Wang Q;Liu Y;Yan H;Wang M;Chen YQ
通讯作者：
Chen YQ
影响因子：
30.3
作者：
Ai, Jingwen;Wang, Xun;He, Xinyi;Zhao, Xiaoyu;Zhang, Yi;Jiang, Yuchao;Li, Minghui;Cui, Yuchen;Chen, Yanjia;Qiao, Rui;Li, Lin;Yang, Lulu;Li, Yi;Hu, Zixin;Zhang, Wenhong;Wang, Pengfei
通讯作者：
Wang, Pengfei