Molecular Mechanisms of Cancer Prevention by Gooseberry (Phyllanthus emblica).
Molecular Mechanisms of Cancer Prevention by Gooseberry (Phyllanthus emblica).
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DOI：
10.1080/01635581.2021.2008988
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发表时间：
2022
期刊：
影响因子：
--
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中科院分区：
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印度醋栗(余甘子或余甘子)在印度传统医学(阿育吠陀)中有着公认的历史。醋栗被认为是一种饮食补充剂，具有多种治疗作用。植物的许多部分(果实、种子、叶、根、树皮和花)具有不同的活性，用于治疗一系列疾病。本文综述了猕猴桃、猕猴桃提取物及其主要植物化学物质在体外和体内研究的抗癌作用证据。最重要的是，在多种啮齿动物的癌症模型中，发现余甘子的治疗可以防止不同器官部位的肿瘤发生率、数量和体积。猕猴桃介导的癌症抑制机制(S)是多样的，包括抗氧化剂、I期和II期酶修饰、抗炎作用、细胞周期调节和致癌信号基因调控。对人体的研究也表明，余甘子可以提供各种健康益处，并与其他治疗方法协同作用。该综述提供了醋栗提取物在人类中作为抗癌药物的潜在用途的详细信息，阐明了其治疗应用，并讨论了临床试验。
Indian gooseberry (Emblica officinalis Gaertn or Phyllanthus emblica Linn; family Phyllanthaceae) has a recognized history in Indian traditional medicine (Ayurveda). Various therapeutic properties have been attributed to gooseberry as a dietary supplement. Many parts of the plant (fruits, seed, leaves, root, bark, and flowers) possess various activities and are used to treat a range of diseases. This review focuses on the evidence for the cancer-preventive properties of gooseberry, its extracts, and its principal phytochemicals based on studies In Vitro and In Vivo. Most importantly, in multiple rodent models of cancer, treatment with P. emblica was found to prevent tumor incidence, number, and volume at various organ sites. The mechanism(s) implicated in gooseberry-mediated cancer inhibition are diverse and include antioxidants, Phase I and II enzyme modifications, anti-inflammatory action, regulation of the cell cycle, and modulation of oncogenic signaling genes. Studies in humans also indicate that P. emblica can offer various health benefits and synergize with other treatments. This review provides detailed information on the potential use of gooseberry extract as an anticarcinogenic in humans, illuminates the therapeutic applications, and discusses clinical trials.
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DOI：
10.2478/v10001-010-0009-4
发表时间：
2010-01-01
影响因子：
2
作者：
Chakraborty, Devjani;Verma, Ramtej
通讯作者：
Verma, Ramtej
影响因子：
2.4
作者：
Khanna, Savita;Das, Amitava;Roy, Sashwati
通讯作者：
Roy, Sashwati
影响因子：
2
作者：
Kumar, KB;Sabu, MC;Kuttan, R
通讯作者：
Kuttan, R
影响因子：
0.7
作者：
Fatima N;Pingali U;Pilli R
通讯作者：
Pilli R
影响因子：
4
作者：
Kumaran, A.;Karunakaran, R. Joel
通讯作者：
Karunakaran, R. Joel