A systematic review and meta-analysis of the association between HOTAIR polymorphisms and susceptibility to breast cancer.
A systematic review and meta-analysis of the association between HOTAIR polymorphisms and susceptibility to breast cancer.
复制标题
HOTAIR 多态性与乳腺癌易感性之间关联的系统回顾和荟萃分析
DOI：
10.5114/aoms.2019.87537
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Jiang D
中科院分区：
文献类型：
--
作者：
Wang B;Yuan F;Zhang F;Miao Z;Jiang D
引言许多研究都提请注意HOTAIR多态性和乳腺癌易感性的关联，而结果仍然不一致。我们对四种常见HOTAIR多态性与乳腺癌易感性的关系进行了荟萃分析。材料和方法在PubMed、Embase、科克伦图书馆数据库和Web of Science数据库中检索了截至2019年7月的合格已发表文章。使用95%置信区间的比值比来确定lncRNA HOTAIR多态性与乳腺癌风险之间的潜在联系。结果4个SNP在所有遗传模型中均无显著性差异。汇总分析发现rs1899663多态性与乳腺癌易感性降低之间的关键联系，在五个遗传模型中，而不是在医院为基础的对照亚组中的主导模型。对于rs920778多态性，我们发现它在西亚亚组内的隐性、纯合和杂合模型下显著降低了乳腺癌风险，而在东亚亚组内的等位基因和显性模型下增加了乳腺癌风险。此外，rs920778多态性在隐性和杂合子模型下降低了以医院为基础的对照亚组的乳腺癌风险。然而，在总体和分层分析中，未观察到rs4759314多态性与乳腺癌风险之间存在显著相关性。对于rs12826786多态性，在以医院为基础的对照亚组中，在隐性、纯合子和杂合子模型下，它与乳腺癌风险降低显著相关。结论HOTAIR基因rs920778、rs1899663和rs12826786多态性可能与乳腺癌易感性有关。
Introduction Many studies are drawing attention to the associations of HOTAIR polymorphisms and susceptibility to breast cancer, while the results remain inconsistent. We conducted a meta-analysis on the association of four common HOTAIR polymorphisms with breast cancer susceptibility. Material and methods Eligible published articles were searched in PubMed, Embase, Cochrane library databases and Web of Science databases up to July 2019. Odds ratios with 95% confidence intervals were used to identify potential links between lncRNA HOTAIR polymorphisms and the risk of breast cancer. Results Our results showed no significance in all genetic models of all four SNPs. Pooled analyses detected crucial links between the rs1899663 polymorphism and decreased susceptibility to breast cancer in five genetic models rather than the dominant model in the hospital-based control subgroup. For the rs920778 polymorphism, we found that it significantly decreased breast cancer risk under recessive, homozygous and heterozygous models within the west Asian subgroup and increased breast cancer risk under allele and dominant models within the East Asian subgroup. Additionally, rs920778 polymorphism decreased breast cancer risk under recessive and heterozygous models in the hospital-based control subgroup. However, no significant association was observed between the rs4759314 polymorphism and breast cancer risk in overall and stratified analyses. For rs12826786 polymorphism, it was greatly associated with decreased breast cancer risk under recessive, homozygous and heterozygous models in the hospital-based control subgroup. Conclusions HOTAIR rs920778, rs1899663 and rs12826786 polymorphisms may contribute to breast cancer susceptibility.
登录
查看更多内容
影响因子：
4.7
作者：
Li J;Cui Z;Li H;Lv X;Gao M;Yang Z;Bi Y;Zhou B;Yin Z
通讯作者：
Yin Z
影响因子：
4
作者：
Li, Jia;Liu, Ruijuan;Sun, Changgang
通讯作者：
Sun, Changgang
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
--
作者：
Gong, Wei-Jing;Yin, Ji-Ye;Liu, Zhao-Qian
通讯作者：
Liu, Zhao-Qian
HOTAIR 多态性 rs4759314 和 rs920778 与基于种族和癌症类型的癌症易感性的关联。
影响因子：
--
作者：
Qi Q;Wang J;Huang B;Chen A;Li G;Li X;Wang J
通讯作者：
Wang J