Association of HOTAIR polymorphisms rs4759314 and rs920778 with cancer susceptibility on the basis of ethnicity and cancer type.
Association of HOTAIR polymorphisms rs4759314 and rs920778 with cancer susceptibility on the basis of ethnicity and cancer type.
复制标题
HOTAIR 多态性 rs4759314 和 rs920778 与基于种族和癌症类型的癌症易感性的关联。
DOI：
10.18632/oncotarget.9608
复制
发表时间：
2016-06-21
期刊：
影响因子：
--
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Qi Q;Wang J;Huang B;Chen A;Li G;Li X;Wang J
HOX转录反义基因间RNA（HOTAIR）的多态性最近已与不同癌症的易感性。在这里，进行荟萃分析，以获得更精确的估计参与HOTAIR多态性在癌症的发展。病例（n = 7，772）和对照（n = 9，075）的数据是从合格研究（n = 10）中提取的，这些研究是在PubMed、Embase和Web of Science数据库中进行的综合文献检索中确定的，检索截止日期为2016年1月20日。总的来说，在等位基因对比（OR = 1.239，95%CI = 1.032 - 1.487）和隐性模型（OR = 1.614，95%CI = 1.082 - 2.406）中，多态性rs 920778与癌症风险增加之间的关联是显著的。在基于种族的亚组分析中，在所有模型下，在亚洲人中观察到多态性rs 920778与癌症易感性之间的显著关联，但在隐性（OR = 2.128，95%CI = 1.417 - 3.197）和纯合子模型（OR = 2.764，95%CI = 2.221 - 3.440）下最引人注目。按癌症类型进行的亚组分析显示，在等位基因对比中，多态性rs 4759314与胃癌易感性之间存在显着相关性优势型（OR = 1.262，95% CI = 1.073 - 1.486）、显性型（OR = 1.280，95% CI = 1.060 - 1.547）和杂合子型（OR = 1.288，95% CI = 1.057 - 1.570）。总之，结果表明HOTAIR多态性rs 920778与癌症风险更普遍相关，特别是在亚洲人中，而rs 4759314是胃癌的危险因素。
Polymorphisms in the HOX transcript antisense intergenic RNA (HOTAIR) have been recently associated with susceptibility to different cancers. Here, a meta-analysis was performed to derive a more precise estimation of the involvement of HOTAIR polymorphisms in cancer development. Data from cases (n = 7,772) and controls (n = 9,075) were extracted from eligible studies (n = 10) identified in a comprehensive literature search conducted in PubMed, Embase, and the Web of Science databases through January 20, 2016. Overall, association between polymorphism rs920778 and increased cancer risk was significant in allele contrast (odds ratio (OR) = 1.239, 95% confidence interval (CI) = 1.032 - 1.487) and recessive models (OR = 1.614, 95% CI = 1.082 - 2.406). In subgroup analysis based on ethnicity, a significant association between polymorphism rs920778 and cancer susceptibility was observed in Asians under all models, but was most compelling under recessive (OR = 2.128, 95% CI = 1.417 - 3.197) and homozygous models (OR = 2.764, 95% CI = 2.221 - 3.440). Subgroup analysis by cancer type revealed a significant association between polymorphism rs4759314 and susceptibility to gastric cancer in allele contrast (OR = 1.262, 95% CI = 1.073 - 1.486), dominant (OR = 1.280, 95% CI = 1.060 - 1.547), and heterozygous models (OR = 1.288, 95% CI = 1.057 - 1.570). In conclusion, the results indicated that HOTAIR polymorphism rs920778 was more generally associated with cancer risk, particularly in Asians, while rs4759314 was a risk factor for gastric cancer.
登录
查看更多内容
影响因子：
37.3
作者：
Gibb EA;Brown CJ;Lam WL
通讯作者：
Lam WL
DOI：
10.1016/j.bbcan.2015.07.001
发表时间：
2015-08
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Bhan A;Mandal SS
通讯作者：
Mandal SS
影响因子：
--
作者：
Su X;Malouf GG;Chen Y;Zhang J;Yao H;Valero V;Weinstein JN;Spano JP;Meric-Bernstam F;Khayat D;Esteva FJ
通讯作者：
Esteva FJ
中国人群lncRNA HOTAIR基因变异与胃癌风险的关联分析
影响因子：
--
作者：
Du M;Wang W;Jin H;Wang Q;Ge Y;Lu J;Ma G;Chu H;Tong N;Zhu H;Wang M;Qiang F;Zhang Z
通讯作者：
Zhang Z
影响因子：
2.2
作者：
Bayram, Suleyman;Ulger, Yakup;Rencuzogullari, Eyyup
通讯作者：
Rencuzogullari, Eyyup