Role of parental divorce and discord in the intergenerational transmission of alcohol use disorder.
Role of parental divorce and discord in the intergenerational transmission of alcohol use disorder.
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DOI：
10.1016/j.drugalcdep.2022.109404
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发表时间：
2022-05-01
影响因子：
4.2
通讯作者：
Kendler, Kenneth S.
中科院分区：
文献类型：
--
作者：
Salvatore, Jessica E.;Aggen, Steven H.;Kendler, Kenneth S.
酒精使用障碍（AUD）具有很强的家族成分，与离婚和关系不和谐有关。本研究的目的是测试父母离婚和父母关系不和谐是否有助于AUD的代际传播。样本包括来自弗吉尼亚精神和物质使用障碍成年双胞胎研究的N=9005对成年双胞胎（43%为女性）。参与者AUD诊断来自基于DSM-IV酒精依赖的结构化临床访谈。参与者还报告了父母离婚和父母AUD的情况。此外，直接的精神病学访谈数据和关系不和谐的测量方法可用于女性-女性双胞胎父母的子样本（855名母亲，617名父亲）。使用蒙特卡罗积分的鲁棒极大似然估计器对间接效应模型进行拟合和检验。路径和结构方程建模结果有力地支持了AUD的代际传递，并表明父母的AUD通过暴露于父母离婚和父母关系不和谐对后代AUD有间接影响。对男性和女性的影响是一致的。在以人口为基础的成年双胞胎样本中，暴露于父母离婚和关系不和谐似乎对理解澳元的代际传播很重要。这些影响与遗传培育的观点大体一致，即父母通过家庭环境的遗传因素间接地将酒精使用障碍的遗传风险传递给子女。最终，这一病因学信息可以加强以技能为基础的治疗努力，用于离婚或痛苦家庭的物质相关预防干预。
Alcohol use disorder (AUD) has a strong familial component, and is associated with divorce and relationship discord. The purpose of this study was to test whether exposure to parental divorce and parental relationship discord contributes to the intergenerational transmission of AUD. The sample included N=9005 adult twins (43% female) from the Virginia Adult Twin Study of Psychiatric and Substance Use Disorders. Participant AUD diagnoses were derived from structured clinical interviews based on DSM-IV alcohol dependence. Participants also reported on parental divorce and parental AUD. In addition, direct psychiatric interview data and measures of relationship discord were available for a subsample of parents of female-female twin pairs (855 mothers, 617 fathers). Indirect effects models were fit and tested using a robust maximum likelihood estimator with Monte Carlo integration. Path and structural equation modeling results provided strong support for the intergenerational transmission of AUD, and indicated that parental AUD had indirect effects on offspring AUD through exposure to parental divorce and parental relationship discord. Effects were consistent across males and females. In a population-based adult twin sample, exposure to parental divorce and relationship discord appears to be important for understanding the intergenerational transmission of AUD. These effects are broadly consistent with the idea of genetic nurturance, whereby parents transmit genetic risk for alcohol use disorder to their children indirectly via heritable aspects of the home environment. Ultimately, this etiological information could bolster engagement with skills-based therapeutic efforts used in substance-related preventive interventions for divorced or distressed families.
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