The environmental pollutant, polychlorinated biphenyls, and cardiovascular disease: a potential target for antioxidant nanotherapeutics.
The environmental pollutant, polychlorinated biphenyls, and cardiovascular disease: a potential target for antioxidant nanotherapeutics.
复制标题
DOI：
10.1007/s13346-017-0429-9
复制
发表时间：
2018-06
影响因子：
5.4
通讯作者：
Dziubla T
中科院分区：
文献类型：
--
作者：
Gupta P;Thompson BL;Wahlang B;Jordan CT;Zach Hilt J;Hennig B;Dziubla T
尽管在1970年代已停止生产，但多氯联苯仍是持久性有机污染物，继续对人类健康构成严重威胁。接触多氯联苯与慢性炎症性疾病有关，如心血管疾病、2型糖尿病、肥胖症，以及肝脏疾病、内分泌功能障碍、神经缺陷和许多其他疾病。PCB的强疏水性使其进一步复杂化，导致它们能够在食物链中积累并储存在脂肪沉积物中。这意味着完全避免接触是不可能的，因此需要制定干预战略，以减轻与接触多氯联苯有关的疾病风险。目前，使用营养化合物作为抑制与多氯联苯相关的炎症的一种方式令人兴奋，但这些化合物的次优递送和药理学可能不足以用于更急性的暴露。在这篇综述中，我们讨论了PCB毒性和一些抗氧化剂和抗炎纳米载体系统，可能是有用的，作为一种增强的治疗方式，减少PCB毒性的知识的现状。
Despite production having stopped in the 1970s, polychlorinated biphenyls (PCBs) represent persistent organic pollutants that continue to pose a serious human health risk. Exposure to PCBs has been linked to chronic inflammatory diseases, such as cardiovascular disease, type 2 diabetes, obesity, as well as hepatic disorders, endocrine dysfunction, neurological deficits and many others. This is further complicated by PCB’s strong hydrophobicity, resulting in their ability to accumulate up the food chain and to be stored in fat deposits. This means that completely avoiding exposure is not possible, thus requiring the need to develop intervention strategies that can mitigate disease risks associated with exposure to PCBs. Currently, there is excitement in the use of nutritional compounds as a way of inhibiting the inflammation associated with PCBs, yet the suboptimal delivery and pharmacology of these compounds may not be sufficient in more acute exposures. In this review, we discuss the current state of knowledge of PCB toxicity and some of the antioxidant and anti-inflammatory nanocarrier systems that may be useful as an enhanced treatment modality for reducing PCB toxicity.
登录
查看更多内容
影响因子：
11.2
作者：
CHAN, PH;LONGAR, S;FISHMAN, RA
通讯作者：
FISHMAN, RA
影响因子：
7.4
作者：
ARUOMA, OI;HALLIWELL, B;BUTLER, J
通讯作者：
BUTLER, J
影响因子：
11.1
作者：
Bergkvist, C.;Kippler, M.;Akesson, A.
通讯作者：
Akesson, A.
影响因子：
--
作者：
Akbarzadeh A;Rezaei-Sadabady R;Davaran S;Joo SW;Zarghami N;Hanifehpour Y;Samiei M;Kouhi M;Nejati-Koshki K
通讯作者：
Nejati-Koshki K
DOI：
10.1080/15287394.2015.1037412
发表时间：
2015
期刊：
Journal of toxicology and environmental health. Part A
影响因子：
--
作者：
Byrne S;Miller P;Waghiyi V;Buck CL;von Hippel FA;Carpenter DO
通讯作者：
Carpenter DO