Anti-CII antibody as a novel indicator to assess disease activity in systemic lupus erythematosus
Anti-CII antibody as a novel indicator to assess disease activity in systemic lupus erythematosus
复制标题
抗 CII 抗体作为评估系统性红斑狼疮疾病活动性的新指标
DOI：
10.1177/0961203315588970
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发表时间：
2015-11
期刊：
影响因子：
2.6
通讯作者：
Feng, P.
中科院分区：
文献类型：
--
作者：
Song, T.;Qin, C.;Yan, R.;Feng, P.
系统性红斑狼疮(SLE)是一种影响多种器官系统的慢性自身免疫性疾病。50多年来，抗dsDNA抗体和补体因子一直被用作狼疮活动度的指标。本文报道了一种新的系统性红斑狼疮激活指标。与强直性脊柱炎(AS)和健康对照组(HCS)相比，SLE患者抗II型胶原(CII)抗体明显升高。抗CII抗体阳性的SLE患者血清免疫球蛋白水平明显高于对照组，ANA滴度明显高于对照组，而补体C3、C4水平明显低于对照组。系统性红斑狼疮患者抗CII抗体与血清免疫球蛋白呈正相关(r = 为0.0001.5 0，p <； 为0.0 5)。系统性红斑狼疮患者抗CII抗体与补体C3、C4呈负相关(r = -0.36，p = 0.0013；r = -0.37，p = 0.0006)。抗-CII抗体水平下降伴随着常规治疗后血清免疫球蛋白水平下降和补体C3、C4水平升高。因此，抗CII抗体可作为监测SLE活动性的新指标。
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that affects a variety of organ systems. Anti-dsDNA Abs and complement factors have been used as indicators of lupus activity for more than 50 years. A novel indicator of activation in SLE is reported in this paper. Anti-collagen type II (CII) Ab was obviously elevated in patients with SLE compared to those patients with ankylosing spondylitis (AS) and healthy controls (HCs). Anti-CII-Ab-positive patients with SLE showed significantly higher levels of serum IgG and higher titers of ANA but lower levels of C3 and C4 than controls. A positive correlation was demonstrated between anti-CII Ab and serum IgG in SLE patients (r = 0.50, p < 0.0001). The negative correlations of anti-CII Ab with C3 and C4 were observed in SLE patients (r = –0.36, p = 0.0013; r = –0.37, p = 0.0006, respectively). The reduced anti-CII Ab level was accompanied by decreased level of serum IgG and increased levels of C3 and C4 after regular treatment. Therefore, anti-CII Ab could be a novel indicator for monitoring activity of SLE.
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影响因子：
4.9
作者：
Mullazehi M;Wick MC;Klareskog L;van Vollenhoven R;Rönnelid J
通讯作者：
Rönnelid J
影响因子：
2.6
作者：
G. Villarreal;C. Drenkard;A. Villa;H. Slor;S. Shafrir;R. Bakimer;Y. Shoenfeld;D. Alarcon-segovia
通讯作者：
G. Villarreal;C. Drenkard;A. Villa;H. Slor;S. Shafrir;R. Bakimer;Y. Shoenfeld;D. Alarcon-segovia
DOI：
--
发表时间：
2010
期刊：
--
影响因子：
--
作者：
D. Aletaha;T. Neogi;A. Silman;Julia Funovits;D. Felson;C. Bingham;N. Birnbaum;G. Burmester;V. Byker
通讯作者：
D. Aletaha;T. Neogi;A. Silman;Julia Funovits;D. Felson;C. Bingham;N. Birnbaum;G. Burmester;V. Byker
影响因子：
--
作者：
VALENTIJN, RM;VANOVERHAGEN, H;VANES, LA
通讯作者：
VANES, LA
影响因子：
3.7
作者：
Yong-Beom Park;S. Lee;Dong Soo Kim;Junga Lee;C. Lee;C. Song
通讯作者：
Yong-Beom Park;S. Lee;Dong Soo Kim;Junga Lee;C. Lee;C. Song