Cerebellar contributions across behavioural timescales: a review from the perspective of cerebro-cerebellar interactions.

Cerebellar contributions across behavioural timescales: a review from the perspective of cerebro-cerebellar interactions.
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DOI:
10.3389/fnsys.2023.1211530
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发表时间:
2023
影响因子:
3
通讯作者:
Cerminara, Nadia L.
Cerminara, Nadia L.
中科院分区:
医学3区
文献类型:
--
作者:
Boven, Ellen;Cerminara, Nadia L.

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成功的适应性行为依赖于我们以一定的精度处理大范围时间间隔的能力。关于小脑在时间信息加工中的作用的研究采用了小脑参与亚秒加工的教条。然而,新出现的证据表明,小脑可能也参与了超秒级的时间处理。在这里,我们回顾了小脑和大脑皮层之间的互易环,并提供了大脑-小脑相互作用的理论解释,重点是小脑输出如何在复杂序列的学习过程中调节大脑处理。最后,我们提出,虽然小脑支持毫秒时间尺度的能力可能是小脑电路的固有能力,但支持超秒时间尺度的能力可能源于小脑与其他大脑区域的相互作用,如前额叶皮质。
Performing successful adaptive behaviour relies on our ability to process a wide range of temporal intervals with certain precision. Studies on the role of the cerebellum in temporal information processing have adopted the dogma that the cerebellum is involved in sub-second processing. However, emerging evidence shows that the cerebellum might be involved in suprasecond temporal processing as well. Here we review the reciprocal loops between cerebellum and cerebral cortex and provide a theoretical account of cerebro-cerebellar interactions with a focus on how cerebellar output can modulate cerebral processing during learning of complex sequences. Finally, we propose that while the ability of the cerebellum to support millisecond timescales might be intrinsic to cerebellar circuitry, the ability to support supra-second timescales might result from cerebellar interactions with other brain regions, such as the prefrontal cortex.
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