The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic orthostatic hypotension and associated supine hypertension.
The recommendations of a consensus panel for the screening, diagnosis, and treatment of neurogenic orthostatic hypotension and associated supine hypertension.
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DOI：
10.1007/s00415-016-8375-x
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发表时间：
2017-08
影响因子：
6
通讯作者：
Kaufmann H
中科院分区：
文献类型：
--
作者：
Gibbons CH;Schmidt P;Biaggioni I;Frazier-Mills C;Freeman R;Isaacson S;Karabin B;Kuritzky L;Lew M;Low P;Mehdirad A;Raj SR;Vernino S;Kaufmann H
神经源性直立性低血压（nOH）常见于神经退行性疾病患者，如帕金森病、多系统萎缩、纯自主神经功能衰竭、路易体痴呆和周围神经病（包括淀粉样蛋白或糖尿病性神经病）。由于nOH在老龄化人群中的频率，临床医生需要充分了解其诊断和管理。迄今为止，nOH的研究使用了不同的结局指标和各种诊断方法，从而阻止了循证指南的产生，指导临床医生在治疗nOH和相关仰卧位高血压患者时采用“最佳实践”。为了解决这些问题，美国自主学会和国家帕金森基金会发起了一个项目，以制定一份建议声明，从2015年11月7日在波士顿举行的共识小组会议开始，到2016年10月，继续沟通和对建议的贡献。本文总结了专家组成员在首次会议期间的讨论，沿着专家组成员之间的持续讨论，并根据现有最佳证据和专家意见，为nOH的（1）筛查、（2）诊断、（3）治疗和（4）相关仰卧位高血压的诊断和治疗提供了基本建议。本文的在线版本（doi：10.1007/s 00415 -016-8375-x）包含补充材料，可供授权用户使用。
Neurogenic orthostatic hypotension (nOH) is common in patients with neurodegenerative disorders such as Parkinson’s disease, multiple system atrophy, pure autonomic failure, dementia with Lewy bodies, and peripheral neuropathies including amyloid or diabetic neuropathy. Due to the frequency of nOH in the aging population, clinicians need to be well informed about its diagnosis and management. To date, studies of nOH have used different outcome measures and various methods of diagnosis, thereby preventing the generation of evidence-based guidelines to direct clinicians towards ‘best practices’ when treating patients with nOH and associated supine hypertension. To address these issues, the American Autonomic Society and the National Parkinson Foundation initiated a project to develop a statement of recommendations beginning with a consensus panel meeting in Boston on November 7, 2015, with continued communications and contributions to the recommendations through October of 2016. This paper summarizes the panel members’ discussions held during the initial meeting along with continued deliberations among the panel members and provides essential recommendations based upon best available evidence as well as expert opinion for the (1) screening, (2) diagnosis, (3) treatment of nOH, and (4) diagnosis and treatment of associated supine hypertension. The online version of this article (doi:10.1007/s00415-016-8375-x) contains supplementary material, which is available to authorized users.
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影响因子：
3.7
作者：
Guaraldi P;Poda R;Calandra-Buonaura G;Solieri L;Sambati L;Gallassi R;Cortelli P
通讯作者：
Cortelli P
有症状性神经源性体性低血压患者的随机戒断研究反应了龙氧化疾病。
DOI：
10.1161/hypertensionaha.114.04035
发表时间：
2015-01
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Biaggioni I;Freeman R;Mathias CJ;Low P;Hewitt LA;Kaufmann H;Droxidopa 302 Investigators
通讯作者：
Droxidopa 302 Investigators
影响因子：
9.9
作者：
Gibbons, Christopher H.;Freeman, Roy
通讯作者：
Freeman, Roy
影响因子：
168.9
作者：
Henry, R;Rowe, J;O'Mahony, D
通讯作者：
O'Mahony, D
DOI：
10.1152/ajpgi.00163.2002
发表时间：
2003-04-01
影响因子：
4.5
作者：
Berry, MK;Russo, A;Jones, KL
通讯作者：
Jones, KL