Olfactory receptors in non-chemosensory tissues.
Olfactory receptors in non-chemosensory tissues.
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DOI：
10.5483/bmbrep.2012.45.11.232
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发表时间：
2012-11
期刊：
影响因子：
3.8
通讯作者：
Koo J
中科院分区：
文献类型：
--
作者：
Kang N;Koo J
嗅觉感受器（ORs）检测挥发性化学物质，导致大脑对气味的最初感知。嗅觉受体（OR）是第一个在嗅觉信号通路中识别气味的蛋白质，它存在于小鼠的1,000多个基因中。它也是G蛋白偶联受体（GPCR）中最大的成员。大多数OR在鼻嗅上皮中广泛表达，在鼻嗅上皮中它们执行适合其位置的适当生理功能。然而，最近的全基因组测序显示，已发现的ORs的嗅觉系统之外，这表明ORs可能发挥重要作用的异位表达的非化学感受组织。随着MOR 23和睾丸hOR 17 -4分别参与骨骼肌的发育、再生和人类精子的趋化性，ORs的异位表达及其生理功能受到越来越多的关注。当鉴定非嗅觉组织中OR的额外表达谱和功能时，存在可用于类似OR基因的少量抗体所带来的限制。这篇综述介绍了一系列研究的结果，确定异位表达和功能的OR在非化学感受组织提供洞察未来的研究方向。[BMB报告2012; 45（11）：612-622]
Olfactory receptors (ORs) detect volatile chemicals that lead to the initial perception of smell in the brain. The olfactory receptor (OR) is the first protein that recognizes odorants in the olfactory signal pathway and it is present in over 1,000 genes in mice. It is also the largest member of the G protein-coupled receptors (GPCRs). Most ORs are extensively expressed in the nasal olfactory epithelium where they perform the appropriate physiological functions that fit their location. However, recent whole-genome sequencing shows that ORs have been found outside of the olfactory system, suggesting that ORs may play an important role in the ectopic expression of non-chemosensory tissues. The ectopic expressions of ORs and their physiological functions have attracted more attention recently since MOR23 and testicular hOR17-4 have been found to be involved in skeletal muscle development, regeneration, and human sperm chemotaxis, respectively. When identifying additional expression profiles and functions of ORs in non-olfactory tissues, there are limitations posed by the small number of antibodies available for similar OR genes. This review presents the results of a research series that identifies ectopic expressions and functions of ORs in non-chemosensory tissues to provide insight into future research directions. [BMB Reports 2012; 45(11): 612-622]
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影响因子：
11.8
作者：
Griffin CA;Kafadar KA;Pavlath GK
通讯作者：
Pavlath GK
影响因子：
10.7
作者：
De la Cruz, Omar;Blekhman, Ran;Gilad, Yoav
通讯作者：
Gilad, Yoav
影响因子：
3.4
作者：
Fuss, SH;Omura, M;Mombaerts, P
通讯作者：
Mombaerts, P
DOI：
10.1006/bbrc.1997.8041
发表时间：
1998-01-26
影响因子：
3.1
作者：
Blache, P;Gros, L;Bataille, D
通讯作者：
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DOI：
10.1006/bbrc.1996.0580
发表时间：
1996-04-16
影响因子：
3.1
作者：
Asai, H;Kasai, H;Tsuboi, A
通讯作者：
Tsuboi, A