Sex matters: impact on pathogenesis, presentation and treatment of inflammatory bowel disease.
Sex matters: impact on pathogenesis, presentation and treatment of inflammatory bowel disease.
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DOI：
10.1038/s41575-020-0354-0
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发表时间：
2020-12
期刊：
影响因子：
--
通讯作者：
Pizarro TT
中科院分区：
文献类型：
--
作者：
Goodman WA;Erkkila IP;Pizarro TT
炎症性肠病（IBD）与大多数慢性炎症性疾病一样，在男性和女性患者中显示出独特的特征并赋予不同的风险因素。重要的是，IBD在不同年龄组的流行病学发病率和患病率存在性别差异，男性和女性出现不同的临床症状和疾病严重程度的差异。此外，IBD中合并症的表现显示出强烈的性别差异。值得注意的是，女性健康特有的特殊问题，包括怀孕和分娩，需要对育龄期IBD女性患者进行特殊考虑，这可能对临床结局产生重大影响。本文综述了IBD患者在流行病学、临床病程、合并症和对当前治疗反应方面的性别差异的最新研究结果。重要的是，对这一研究领域的最新基础科学发现进行了评估，以深入了解性别对疾病发病机制影响的潜在机制，并为IBD患者设计更加个性化和有效的护理。
Inflammatory bowel disease (IBD), as do most chronic inflammatory disorders, displays unique features and confers different risk factors in male and female patients. Importantly, sex-based differences in IBD exist for epidemiological incidence and prevalence among different age groups, with men and women developing distinct clinical symptoms and disparity in severity of disease. In addition, the presentation of comorbidities in IBD displays strong sex differences. Notably, particular issues exclusive to women’s health, including pregnancy and childbirth, require specific considerations in female patients with IBD of childbearing age that can have a substantial influence on clinical outcomes. This Review summarizes the latest findings regarding sex-based differences in the epidemiology, clinical course, comorbidities and response to current therapies in patients with IBD. Importantly, the latest basic science discoveries in this area of investigation are evaluated to provide insight into potential mechanisms underlying the influence of sex on disease pathogenesis, as well as to design more personalized and efficacious care, in patients with IBD.
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DOI：
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发表时间：
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