Mammal-like organization of the avian midbrain central gray and a reappraisal of the intercollicular nucleus.
Mammal-like organization of the avian midbrain central gray and a reappraisal of the intercollicular nucleus.
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DOI：
10.1371/journal.pone.0020720
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Goodson JL
中科院分区：
文献类型：
--
作者：
Kingsbury MA;Kelly AM;Schrock SE;Goodson JL
在哺乳动物中，中脑导水管周围灰质（PAG）的轴尾柱调节多种行为和生理功能，包括性行为和战斗或逃跑行为，但在非哺乳动物物种中尚未发现同源柱。哺乳动物的 PAG 位于上丘腹侧并围绕脑导水管，而鸟类则表现出肥大的顶盖横向移位，因此中脑中央灰质 (CG) 向内侧延伸，而不是像哺乳动物那样向背腹侧延伸。因此，我们假设鸟类 CG 的组织方式很像折叠打开的 PAG。为了解决这一假设，我们对小鼠和雀类的中脑进行了免疫组织化学比较，并对领地性和群居性雀类物种的攻击性优势、从属性、非社会防御和性行为进行了 Fos 研究。基于 PAG 的折叠开放模型，我们的预测获得了极好的支持，并进一步表明鸟类具有与哺乳动物类似的形成纵向柱的功能和解剖区域。然而，背侧/背外侧 PAG 的显着特征，例如密集的肽能神经支配、神经元一氧化氮合酶神经元的纵向柱以及攻击性诱导的 Fos 反应，并不位于经典鸟类 CG 内，而是位于横向相邻的丘间核 (ICo) 中，这表明 ICo 的大部分与背侧 PAG 同源。
In mammals, rostrocaudal columns of the midbrain periaqueductal gray (PAG) regulate diverse behavioral and physiological functions, including sexual and fight-or-flight behavior, but homologous columns have not been identified in non-mammalian species. In contrast to mammals, in which the PAG lies ventral to the superior colliculus and surrounds the cerebral aqueduct, birds exhibit a hypertrophied tectum that is displaced laterally, and thus the midbrain central gray (CG) extends mediolaterally rather than dorsoventrally as in mammals. We therefore hypothesized that the avian CG is organized much like a folded open PAG. To address this hypothesis, we conducted immunohistochemical comparisons of the midbrains of mice and finches, as well as Fos studies of aggressive dominance, subordinance, non-social defense and sexual behavior in territorial and gregarious finch species. We obtained excellent support for our predictions based on the folded open model of the PAG and further showed that birds possess functional and anatomical zones that form longitudinal columns similar to those in mammals. However, distinguishing characteristics of the dorsal/dorsolateral PAG, such as a dense peptidergic innervation, a longitudinal column of neuronal nitric oxide synthase neurons, and aggression-induced Fos responses, do not lie within the classical avian CG, but in the laterally adjacent intercollicular nucleus (ICo), suggesting that much of the ICo is homologous to the dorsal PAG.
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