Application of Materials as Medical Devices with Localized Drug Delivery Capabilities for Enhanced Wound Repair.
Application of Materials as Medical Devices with Localized Drug Delivery Capabilities for Enhanced Wound Repair.
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DOI：
10.1016/j.pmatsci.2017.06.003
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发表时间：
2017-08
影响因子：
37.4
通讯作者：
Choy YB
中科院分区：
文献类型：
--
作者：
Lee EJ;Huh BK;Kim SN;Lee JY;Park CG;Mikos AG;Choy YB
可利用种类丰富的天然和合成材料来适应不同的伤口类型以及愈合过程的不同阶段。预计有一种理想的材料可以促进组织修复，同时给患者带来的不便最小化。临床环境中使用的传统材料经常引起继发性并发症，例如感染、疼痛、异物反应和慢性炎症。本综述调查了具有药物洗脱功能的手术缝合线、伤口敷料、手术胶水、骨科固定装置和骨填充剂的全部内容。它强调了为有效地将药物融入所选材料或材料混合物中以进行软组织和硬组织修复而开发的各种技术。还讨论了所得材料的机械和化学属性，以及它们在体外和/或体内的生物学结果。还描述了下一代伤口修复材料未来研究工作的前景和挑战。
The plentiful assortment of natural and synthetic materials can be leveraged to accommodate diverse wound types, as well as different stages of the healing process. An ideal material is envisioned to promote tissue repair with minimal inconvenience for patients. Traditional materials employed in the clinical setting often invoke secondary complications, such as infection, pain, foreign body reaction, and chronic inflammation. This review surveys the repertoire of surgical sutures, wound dressings, surgical glues, orthopedic fixation devices and bone fillers with drug eluting capabilities. It highlights the various techniques developed to effectively incorporate drugs into the selected material or blend of materials for both soft and hard tissue repair. The mechanical and chemical attributes of the resultant materials are also discussed, along with their biological outcomes in vitro and/or in vivo. Perspectives and challenges regarding future research endeavors are also delineated for next-generation wound repair materials.
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