Hyperbilirubinemia and language delay in premature infants.
Hyperbilirubinemia and language delay in premature infants.
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DOI：
10.1542/peds.2007-3723
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发表时间：
2009-01
期刊：
影响因子：
8
通讯作者：
Myers G
中科院分区：
文献类型：
--
作者：
Amin SB;Prinzing D;Myers G
评估早产儿3岁时的语言发育迟缓是否与出生后前两周暴露于高胆红素血症有关。我们对2003年1月至10月间入住新生儿重症监护室的婴儿进行了回顾性病例对照研究。入选标准包括出生体重≤ 1500 g和随访至3岁。排除标准包括遗传性疾病和听力损失或复发性耳部感染。测定前两周内血清总胆红素（TSB）峰值和高胆红素血症持续时间（TSB > 8 mg/dl的天数）。通过发育临床图表和跟踪程序确定了3岁时接受语言治疗的语言发育迟缓婴儿，并与语言发育正常的婴儿进行了比较。2003年1月至10月期间，125名出生体重≤ 1500克的婴儿入住新生儿重症监护室。15名婴儿死亡，110人出院回家。102/110（93%）的婴儿随访至3岁。排除了4名婴儿（1名遗传性疾病，3名迟发性听力损失或复发性耳部感染）。24例患儿语言发育迟缓，接受了语言治疗，74例患儿语言发育正常。两组间TSB峰值和高胆红素血症持续时间无显著差异。在逻辑回归分析中，只有支气管肺发育不良与语言发育迟缓相关（校正优势比7.3，95%置信区间2.5 - 22）。高胆红素血症定义为TSB峰值水平或胆红素升高持续天数，与早产儿语言发育迟缓无关。然而，这个问题值得研究，因为胆红素的其他指标，如未结合胆红素可能与语言延迟有关。
To evaluate if language delay at three years in premature infants is associated with prior exposure to hyperbilirubinemia during the first two weeks after birth. We performed retrospective case-control study of infants admitted to the Neonatal Intensive Care Unit between January and October 2003. Inclusion criteria included a birth weight ≤ 1500 grams and follow-up to age three years. Exclusion criteria included genetic disorders and hearing loss or recurrent ear infections. Peak total serum bilirubin (TSB) during the first two weeks and duration of hyperbilirubinemia (days with TSB > 8 mg/dl) were determined. Infants with language delay and receiving speech therapy by three years were identified through developmental clinic charts and tracking program and compared to infants who had normal language development. 125 infants with birth weight ≤ 1500 grams were admitted to the Neonatal Intensive Care Unit between January and October 2003. Fifteen infants died and 110 were discharged home. 102/110 (93%) of infants had follow-up to age three years. Four infants were excluded (1 genetic disorder, 3 delayed hearing loss or recurrent ear infections). 24 infants had a language delay and received speech therapy while 74 infants had normal language development. There was no significant difference in peak TSB and duration of hyperbilirubinemia between the two groups. On logistic regression, only bronchopulmonary dysplasia was associated with language delay (Adjusted odds ratio 7.3, 95% confidence interval 2.5 – 22). Hyperbilirubinemia defined as peak TSB level or duration of elevated bilirubin in days is not associated with language delay in premature infants. However, this issue deserves investigation since other measures of bilirubin, such as unbound bilirubin may be associated with language delay.
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影响因子：
2.5
作者：
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通讯作者：
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影响因子：
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作者：
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发表时间：
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影响因子：
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