Methylmercury, attention, and memory: baseline-dependent effects of adult d-amphetamine and marginal effects of adolescent methylmercury.
Methylmercury, attention, and memory: baseline-dependent effects of adult d-amphetamine and marginal effects of adolescent methylmercury.
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DOI：
10.1016/j.neuro.2020.07.009
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发表时间：
2020-09
期刊：
影响因子：
3.4
通讯作者：
Newland, M. Christopher
中科院分区：
文献类型：
--
作者：
Kendricks, Dalisa R.;Boomhower, Steven R.;Newland, M. Christopher
甲基汞（MeHg）是一种环境神经毒物，已知在实验模型中会破坏与多巴胺神经传递相关的行为。当接触甲基汞后立即给药或与接触甲基汞同时给药时，这种干扰对多巴胺激动剂敏感。持续注意力和短期记忆，注意力缺陷/多动障碍（ADHD）的组成部分，部分由多巴胺神经传递介导。为了观察持续注意力和短期记忆的甲基汞相关改变，以及确定甲基汞暴露动物对常用于治疗ADHD症状的多巴胺激动剂的敏感性，大鼠在整个青春期暴露于0、0.5或5 ppm的甲基汞，并在成年期接受混合持续注意力/短期记忆视觉信号检测任务的训练。然后通过急性腹膜内注射多巴胺激动剂d-安非他明来探测行为，d-安非他明改善了注意力受损，抑制了ADHD等临床综合征的短期记忆。急性d-安非他明剂量依赖性地降低短期记忆以及持续的注意力。虽然单独的甲基汞不会损害准确性或记忆力，但它确实与d-安非他明相互作用，产生基线依赖的行为抑制。这些研究结果进一步表明，在青春期低水平接触甲基汞后，多巴胺激动剂会增强行为变化。急性d-安非他明后观察到的记忆障碍与以前的研究结果一致。
Methylmercury (MeHg) is an environmental neurotoxicant known to disrupt behavior related to dopamine neurotransmission in experimental models. Such disruptions are sensitive to dopamine agonists when administered acutely after exposure to MeHg has ended or when administered concurrently with MeHg exposure. Sustained attention and short-term remembering, components of attention-deficit/hyperactivity disorder (ADHD), are partially mediated by dopamine neurotransmission. In order to observe MeHg-related alterations in sustained attention and short-term memory, as well as determine sensitivity of MeHg exposed animals to dopamine agonists commonly used in the treatment of ADHD symptoms, rats were exposed to 0, 0.5, or 5 ppm MeHg throughout adolescence and trained in a hybrid sustained attention/short term memory visual signal detection task in adulthood. Behavior was then probed with acute i.p. injections of the dopamine agonist, d-amphetamine, which improves impaired attention and inhibits short-term memory in clinical syndromes like ADHD. Acute d-amphetamine dose-dependently decreased short-term memory as well as sustained attention. While MeHg alone did not impair accuracy or memory, it did interact with d-amphetamine to produce baseline-dependent inhibition of behavior. These findings further show that changes in behavior following low-level exposure to MeHg during adolescence are augmented by dopamine agonists. Observed impairments in memory following acute d-amphetamine are consistent with previous findings.
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